Publication:
Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review

dc.contributor.authorToledano-Osorio, Manuel
dc.contributor.authorVallecillo, Cristina
dc.contributor.authorVallecillo-Rivas, Marta
dc.contributor.authorManzano-Moreno, Francisco-Javier
dc.contributor.authorOsorio, Raquel
dc.contributor.authoraffiliation[Toledano-Osorio, Manuel] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain
dc.contributor.authoraffiliation[Vallecillo, Cristina] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain
dc.contributor.authoraffiliation[Vallecillo-Rivas, Marta] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain
dc.contributor.authoraffiliation[Manzano-Moreno, Francisco-Javier] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain
dc.contributor.authoraffiliation[Osorio, Raquel] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain
dc.contributor.authoraffiliation[Manzano-Moreno, Francisco-Javier] Univ Granada, Fac Odontol, Dept Stomatol, Biomed Grp BI0277, Granada 18071, Spain
dc.contributor.authoraffiliation[Manzano-Moreno, Francisco-Javier] Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, C Doctor Azpitarte 4, Granada 18012, Spain
dc.contributor.funderMinistry of Economy and Competitiveness (MINECO)
dc.contributor.funderEuropean Regional Development Fund (FEDER)
dc.contributor.funderMinistry of Universities
dc.contributor.funderMinistry of Economy and Competitiveness (MINECO) and the European Regional Development Fund (FEDER),
dc.contributor.funderMinistry of Universities
dc.date.accessioned2023-05-03T14:21:48Z
dc.date.available2023-05-03T14:21:48Z
dc.date.issued2022-02-14
dc.description.abstractPolymeric membranes are frequently used for bone regeneration in oral and periodontal surgery. Polymers provide adequate mechanical properties (i.e., Young's modulus) to support oral function and also pose some porosity with interconnectivity to permit for cell proliferation and migration. Bacterial contamination of the membrane is an event that may lead to infection at the bone site, hindering the clinical outcomes of the regeneration procedure. Therefore, polymeric membranes have been proposed as carriers for local antibiotic therapy. A literature search was performed for papers, including peer-reviewed publications. Among the different membranes, collagen is the most employed biomaterial. Collagen membranes and expanded polytetrafluoroethylene loaded with tetracyclines, and polycaprolactone with metronidazole are the combinations that have been assayed the most. Antibiotic liberation is produced in two phases. A first burst release is sometimes followed by a sustained liberation lasting from 7 to 28 days. All tested combinations of membranes and antibiotics provoke an antibacterial effect, but most of the time, they were measured against single bacteria cultures and usually non-specific pathogenic bacteria were employed, limiting the clinical relevance of the attained results. The majority of the studies on animal models state a beneficial effect of these antibiotic functionalized membranes, but human clinical assays are scarce and controversial.
dc.description.versionSi
dc.identifier.citationToledano-Osorio M, Vallecillo C, Vallecillo-Rivas M, Manzano-Moreno FJ, Osorio R. Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review. Polymers (Basel). 2022 Feb 21;14(4):840.
dc.identifier.doi10.3390/polym14040840
dc.identifier.essn2073-4360
dc.identifier.unpaywallURLhttps://www.mdpi.com/2073-4360/14/4/840/pdf?version=1645587516
dc.identifier.urihttp://hdl.handle.net/10668/21564
dc.identifier.wosID916116700001
dc.issue.number4
dc.journal.titlePolymers
dc.journal.titleabbreviationPolymers
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.provenanceRealizada la curación de contenido 12/08/2024
dc.publisherMDPI AG
dc.relation.projectIDPID2020-114694RB-I00 MINECO/AEI/FEDER/UE
dc.relation.projectIDFPU20/00450
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=polym14040840
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbarrier membrane
dc.subjectpolymer
dc.subjectcollagen
dc.subjectantibiotic
dc.subjectbone regeneration
dc.subjectTissue regeneration
dc.subjectBone regeneration
dc.subjectAntibacterial efficacy
dc.subjectBacterial adhesion
dc.subjectCollagen membrane
dc.subjectTetracycline
dc.subjectRelease
dc.subjectMetronidazole
dc.subjectDefects
dc.subjectAttachment
dc.subject.decsAntibacterianos
dc.subject.decsBacterias
dc.subject.decsColágeno
dc.subject.decsInhibidores de la síntesis de la proteína
dc.subject.decsMateriales biocompatibles
dc.subject.decsMetronidazol
dc.subject.decsPolitetrafluoroetileno
dc.subject.decsPolímeros
dc.subject.decsPorosidad
dc.subject.decsProliferación celular
dc.subject.decsRegeneración ósea
dc.subject.decsRelevancia clínica
dc.subject.decsTetraciclinas
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshMetronidazole
dc.subject.meshpolycaprolactone
dc.subject.meshPolymers
dc.subject.meshBiocompatible Materials
dc.subject.meshTetracyclines
dc.subject.meshPolytetrafluoroethylene
dc.subject.meshPorosity
dc.subject.meshClinical Relevance
dc.subject.meshProtein Synthesis Inhibitors
dc.subject.meshCollagen
dc.subject.meshBacteria
dc.subject.meshBone Regeneration
dc.subject.meshCell Proliferation
dc.titleAntibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review
dc.typereview
dc.type.hasVersionVoR
dc.volume.number14
dc.wostypeReview
dspace.entity.typePublication

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