Publication: Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review
dc.contributor.author | Toledano-Osorio, Manuel | |
dc.contributor.author | Vallecillo, Cristina | |
dc.contributor.author | Vallecillo-Rivas, Marta | |
dc.contributor.author | Manzano-Moreno, Francisco-Javier | |
dc.contributor.author | Osorio, Raquel | |
dc.contributor.authoraffiliation | [Toledano-Osorio, Manuel] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Vallecillo, Cristina] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Vallecillo-Rivas, Marta] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Manzano-Moreno, Francisco-Javier] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Osorio, Raquel] Univ Granada, Fac Dent, Colegio Maximo Cartuja S-N, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Manzano-Moreno, Francisco-Javier] Univ Granada, Fac Odontol, Dept Stomatol, Biomed Grp BI0277, Granada 18071, Spain | |
dc.contributor.authoraffiliation | [Manzano-Moreno, Francisco-Javier] Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, C Doctor Azpitarte 4, Granada 18012, Spain | |
dc.contributor.funder | Ministry of Economy and Competitiveness (MINECO) | |
dc.contributor.funder | European Regional Development Fund (FEDER) | |
dc.contributor.funder | Ministry of Universities | |
dc.contributor.funder | Ministry of Economy and Competitiveness (MINECO) and the European Regional Development Fund (FEDER), | |
dc.contributor.funder | Ministry of Universities | |
dc.date.accessioned | 2023-05-03T14:21:48Z | |
dc.date.available | 2023-05-03T14:21:48Z | |
dc.date.issued | 2022-02-14 | |
dc.description.abstract | Polymeric membranes are frequently used for bone regeneration in oral and periodontal surgery. Polymers provide adequate mechanical properties (i.e., Young's modulus) to support oral function and also pose some porosity with interconnectivity to permit for cell proliferation and migration. Bacterial contamination of the membrane is an event that may lead to infection at the bone site, hindering the clinical outcomes of the regeneration procedure. Therefore, polymeric membranes have been proposed as carriers for local antibiotic therapy. A literature search was performed for papers, including peer-reviewed publications. Among the different membranes, collagen is the most employed biomaterial. Collagen membranes and expanded polytetrafluoroethylene loaded with tetracyclines, and polycaprolactone with metronidazole are the combinations that have been assayed the most. Antibiotic liberation is produced in two phases. A first burst release is sometimes followed by a sustained liberation lasting from 7 to 28 days. All tested combinations of membranes and antibiotics provoke an antibacterial effect, but most of the time, they were measured against single bacteria cultures and usually non-specific pathogenic bacteria were employed, limiting the clinical relevance of the attained results. The majority of the studies on animal models state a beneficial effect of these antibiotic functionalized membranes, but human clinical assays are scarce and controversial. | |
dc.description.version | Si | |
dc.identifier.citation | Toledano-Osorio M, Vallecillo C, Vallecillo-Rivas M, Manzano-Moreno FJ, Osorio R. Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review. Polymers (Basel). 2022 Feb 21;14(4):840. | |
dc.identifier.doi | 10.3390/polym14040840 | |
dc.identifier.essn | 2073-4360 | |
dc.identifier.unpaywallURL | https://www.mdpi.com/2073-4360/14/4/840/pdf?version=1645587516 | |
dc.identifier.uri | http://hdl.handle.net/10668/21564 | |
dc.identifier.wosID | 916116700001 | |
dc.issue.number | 4 | |
dc.journal.title | Polymers | |
dc.journal.titleabbreviation | Polymers | |
dc.language.iso | en | |
dc.organization | Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) | |
dc.provenance | Realizada la curación de contenido 12/08/2024 | |
dc.publisher | MDPI AG | |
dc.relation.projectID | PID2020-114694RB-I00 MINECO/AEI/FEDER/UE | |
dc.relation.projectID | FPU20/00450 | |
dc.relation.publisherversion | https://www.mdpi.com/resolver?pii=polym14040840 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | barrier membrane | |
dc.subject | polymer | |
dc.subject | collagen | |
dc.subject | antibiotic | |
dc.subject | bone regeneration | |
dc.subject | Tissue regeneration | |
dc.subject | Bone regeneration | |
dc.subject | Antibacterial efficacy | |
dc.subject | Bacterial adhesion | |
dc.subject | Collagen membrane | |
dc.subject | Tetracycline | |
dc.subject | Release | |
dc.subject | Metronidazole | |
dc.subject | Defects | |
dc.subject | Attachment | |
dc.subject.decs | Antibacterianos | |
dc.subject.decs | Bacterias | |
dc.subject.decs | Colágeno | |
dc.subject.decs | Inhibidores de la síntesis de la proteína | |
dc.subject.decs | Materiales biocompatibles | |
dc.subject.decs | Metronidazol | |
dc.subject.decs | Politetrafluoroetileno | |
dc.subject.decs | Polímeros | |
dc.subject.decs | Porosidad | |
dc.subject.decs | Proliferación celular | |
dc.subject.decs | Regeneración ósea | |
dc.subject.decs | Relevancia clínica | |
dc.subject.decs | Tetraciclinas | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.subject.mesh | Metronidazole | |
dc.subject.mesh | polycaprolactone | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Biocompatible Materials | |
dc.subject.mesh | Tetracyclines | |
dc.subject.mesh | Polytetrafluoroethylene | |
dc.subject.mesh | Porosity | |
dc.subject.mesh | Clinical Relevance | |
dc.subject.mesh | Protein Synthesis Inhibitors | |
dc.subject.mesh | Collagen | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Bone Regeneration | |
dc.subject.mesh | Cell Proliferation | |
dc.title | Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review | |
dc.type | review | |
dc.type.hasVersion | VoR | |
dc.volume.number | 14 | |
dc.wostype | Review | |
dspace.entity.type | Publication |