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Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis.

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dc.contributor.authorO'Valle, Francisco
dc.contributor.authorPeregrina, Magdalena
dc.contributor.authorCrespo-Lora, Vicente
dc.contributor.authorGalindo-Moreno, Pablo
dc.contributor.authorRoman, Maria
dc.contributor.authorPadial-Molina, Miguel
dc.contributor.authorMesa, Francisco
dc.contributor.authorAneiros-Fernandez, Jose
dc.contributor.authorAguilar, David
dc.contributor.authorGonzalez-Rey, Elena
dc.contributor.authorDelgado, Mario
dc.contributor.authorHernandez-Cortes, Pedro
dc.contributor.authoraffiliation[O'Valle,F; Crespo-Lora,V; Aneiros-Fernandez,J; Aguilar,D] Department of Pathology IBIMER, School of Medicine, University of Granada, Granada, Spain. [Peregrina,M] The Spanish Institute of Social Security (INSS), Granada, Spain. [Galindo-Moreno,P; Padial-Molina,M] Oral Surgery and Implant Dentistry Department, School of Dentistry, University of Granada, Granada, Spain. [Roman,M] Plastic Surgery Department, Virgen de las Nieves University Hospital,Granada. [Mesa,F] Periodontics Department, School of Dentistry, University of Granada, Granada, Spain. [Gonzalez-Rey,E; Delgado,M]Parasitology and Biomedicine López-Neyra Institute, CSIC, Armilla, Granada, Spain. [Hernandez-Cortes,P] Orthopedic Surgery Department, San Cecilio University Hospital of Granada, Granada, Spaines
dc.contributor.funderThis investigation was partially supported by Research Group #CTS-138 (Junta de Andalucía, Spain)
dc.date.accessioned2015-12-02T10:21:06Z
dc.date.available2015-12-02T10:21:06Z
dc.date.issued2015
dc.descriptionJournal Article;es
dc.description.abstractBackground. Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis. Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells. The objectives of this investigation were to perform a morphological study of the experimental CIA model, evaluate the effect of TNFα-blocker (etanercept) treatment, and determine the immunohistochemical expression of Msi1 protein. Methods. CIA was induced in 50 male DBA1/J mice for analyses of tissue and serum cytokine; clinical and morphological lesions in limbs; and immunohistochemical expression of Msi1. Results. Clinically, TNFα-blocker treatment attenuated CIA on day 32 after immunization (P < 0.001). Msi1 protein expression was significantly higher in joints damaged by CIA than in those with no lesions (P < 0.0001) and was related to the severity of the lesions (Spearman's rho = 0.775, P = 0.0001). Conclusions. Treatment with etanercept attenuates osteoarticular lesions in the murine CIA model. Osteoarticular expression of Msi1 protein is increased in joints with CIA-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.es
dc.description.versionYeses
dc.identifier.citationO'Valle F, Peregrina M, Crespo-Lora V, Galindo-Moreno P, Roman M, Padial-Molina M, et al. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. Biomed Res Int. 2015:681456es
dc.identifier.doi10.1155/2015/681456
dc.identifier.essn2314-6141
dc.identifier.pmcPMC4433648
dc.identifier.pmid26064941
dc.identifier.urihttp://hdl.handle.net/10668/2097
dc.journal.titleBioMed Research International
dc.language.isoen
dc.publisherHindawi Publishing Corporationes
dc.relation.publisherversionhttp://www.hindawi.com/journals/bmri/2015/681456/abs/es
dc.rights.accessRightsopen access
dc.subjectModelos teóricoses
dc.subjectArtritis experimentales
dc.subjectColágeno tipo IIes
dc.subjectRatoneses
dc.subjectCélulas madre adultases
dc.subjectInmunizaciónes
dc.subjectInmunoglobulina ges
dc.subjectArticulacioneses
dc.subjectAnimaleses
dc.subjectMasculinoes
dc.subjectFactor de necrosis tumoral alfaes
dc.subjectReceptores del factor de necrosis tumorales
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoreticales
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal::Arthritis, Experimentales
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Collagenes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Adult Stem Cellses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Collagen::Fibrillar Collagens::Collagen Type IIes
dc.subject.meshMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Primary Prevention::Immunizationes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin Ges
dc.subject.meshMedical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Jointses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors::Tumor Necrosis Factor-alphaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factores
dc.titleOsteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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