Publication: Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
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2017-05-04
Authors
Sonnenschein, Eva C.
Stierhof, Marc
Goralczyk, Stephan
Vabre, Floriane M.
Pellissier, Leonie
Hanssen, Kine Ostnes
de la Cruz, Mercedes
Diaz, Caridad
de Witte, Peter
Copmans, Danielle
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Pergamon-elsevier science ltd
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Abstract
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 mu M, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity. (C) 2017 Elsevier Ltd. All rights reserved.
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Pseudoalteromonas, Siderophore, Pseudochelin A, NMR, LCMS, Microbial iron transport, Coordination chemistry, Pseudomonas-aeruginosa, Vibrio-cholerae, Mycobacterium-tuberculosis, Siderocalin, Recognition, Acquisition, Pyochelin, Microorganisms