Publication: Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes.
dc.contributor.author | Chiva-Blanch, Gemma | |
dc.contributor.author | Giro, Oriol | |
dc.contributor.author | Cofan, Montserrat | |
dc.contributor.author | Calle-Pascual, Alfonso L | |
dc.contributor.author | Delgado, Elias | |
dc.contributor.author | Gomis, Ramon | |
dc.contributor.author | Jimenez, Amanda | |
dc.contributor.author | Franch-Nadal, Josep | |
dc.contributor.author | Rojo Martinez, Gemma | |
dc.contributor.author | Ortega, Emilio | |
dc.contributor.funder | Spanish Ministry of Health (ISCIII) | |
dc.contributor.funder | FEDER | |
dc.contributor.funder | Spanish Biomedical research Centre in Diabetes and Associated Metabolic Disorder | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | |
dc.contributor.funder | Ministerio de Sanidad y Consumo | |
dc.contributor.funder | Spanish Society of Diabetes | |
dc.contributor.funder | Nicolas Monardes program of the Consejería de Salud de la Junta de Andalucía | |
dc.date.accessioned | 2023-05-03T14:16:06Z | |
dc.date.available | 2023-05-03T14:16:06Z | |
dc.date.issued | 2022-03-25 | |
dc.description.abstract | The identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), α-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes. | |
dc.description.version | Si | |
dc.identifier.citation | Chiva-Blanch G, Giró O, Cofán M, Calle-Pascual AL, Delgado E, Gomis R, et al. Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. Nutrients. 2022 Mar 25;14(7):1368 | |
dc.identifier.doi | 10.3390/nu14071368 | |
dc.identifier.essn | 2072-6643 | |
dc.identifier.pmc | PMC9002701 | |
dc.identifier.pmid | 35405981 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002701/pdf | |
dc.identifier.unpaywallURL | https://doi.org/10.3390/nu14071368 | |
dc.identifier.uri | http://hdl.handle.net/10668/21465 | |
dc.issue.number | 7 | |
dc.journal.title | Nutrients | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 12 | |
dc.provenance | Realizada la curación de contenido 15/04/2025 | |
dc.publisher | MDPI | |
dc.pubmedtype | Journal Article | |
dc.relation.projectID | CB06/03/0017 | |
dc.relation.projectID | C-0060-2012 | |
dc.relation.publisherversion | https://www.mdpi.com/resolver?pii=nu14071368 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Alpha-linolenic acid | |
dc.subject | Fatty acids | |
dc.subject | Linoleic acid | |
dc.subject | Omega-3 fatty acids | |
dc.subject | Type 2 diabetes | |
dc.subject | Worse of glucose metabolism | |
dc.subject.decs | Membranas | |
dc.subject.decs | Glucosa | |
dc.subject.decs | Diabetes Mellitus tipo 2 | |
dc.subject.decs | Ácido linoleico | |
dc.subject.decs | Cromatografía de gases | |
dc.subject.decs | Estado prediabético | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Docosahexaenoic Acids | |
dc.subject.mesh | Eicosapentaenoic Acid | |
dc.subject.mesh | Erythrocytes | |
dc.subject.mesh | Fatty Acids | |
dc.subject.mesh | Fatty Acids, Omega-3 | |
dc.subject.mesh | Female | |
dc.subject.mesh | Glucose | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Incidence | |
dc.subject.mesh | Linoleic Acid | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Vegetables | |
dc.title | Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 14 | |
dspace.entity.type | Publication |