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Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes.

dc.contributor.authorChiva-Blanch, Gemma
dc.contributor.authorGiro, Oriol
dc.contributor.authorCofan, Montserrat
dc.contributor.authorCalle-Pascual, Alfonso L
dc.contributor.authorDelgado, Elias
dc.contributor.authorGomis, Ramon
dc.contributor.authorJimenez, Amanda
dc.contributor.authorFranch-Nadal, Josep
dc.contributor.authorRojo Martinez, Gemma
dc.contributor.authorOrtega, Emilio
dc.contributor.funderSpanish Ministry of Health (ISCIII)
dc.contributor.funderFEDER
dc.contributor.funderSpanish Biomedical research Centre in Diabetes and Associated Metabolic Disorder
dc.contributor.funderMinisterio de Ciencia e Innovación
dc.contributor.funderMinisterio de Sanidad y Consumo
dc.contributor.funderSpanish Society of Diabetes
dc.contributor.funderNicolas Monardes program of the Consejería de Salud de la Junta de Andalucía
dc.date.accessioned2023-05-03T14:16:06Z
dc.date.available2023-05-03T14:16:06Z
dc.date.issued2022-03-25
dc.description.abstractThe identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), α-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes.
dc.description.versionSi
dc.identifier.citationChiva-Blanch G, Giró O, Cofán M, Calle-Pascual AL, Delgado E, Gomis R, et al. Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. Nutrients. 2022 Mar 25;14(7):1368
dc.identifier.doi10.3390/nu14071368
dc.identifier.essn2072-6643
dc.identifier.pmcPMC9002701
dc.identifier.pmid35405981
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002701/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.3390/nu14071368
dc.identifier.urihttp://hdl.handle.net/10668/21465
dc.issue.number7
dc.journal.titleNutrients
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number12
dc.provenanceRealizada la curación de contenido 15/04/2025
dc.publisherMDPI
dc.pubmedtypeJournal Article
dc.relation.projectIDCB06/03/0017
dc.relation.projectIDC-0060-2012
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=nu14071368
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlpha-linolenic acid
dc.subjectFatty acids
dc.subjectLinoleic acid
dc.subjectOmega-3 fatty acids
dc.subjectType 2 diabetes
dc.subjectWorse of glucose metabolism
dc.subject.decsMembranas
dc.subject.decsGlucosa
dc.subject.decsDiabetes Mellitus tipo 2
dc.subject.decsÁcido linoleico
dc.subject.decsCromatografía de gases
dc.subject.decsEstado prediabético
dc.subject.meshAdult
dc.subject.meshDocosahexaenoic Acids
dc.subject.meshEicosapentaenoic Acid
dc.subject.meshErythrocytes
dc.subject.meshFatty Acids
dc.subject.meshFatty Acids, Omega-3
dc.subject.meshFemale
dc.subject.meshGlucose
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshLinoleic Acid
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshVegetables
dc.titleLow Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication

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