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Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study

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dc.contributor.authorNeukam, Karin
dc.contributor.authorEspinosa, Nuria
dc.contributor.authorMerino, Dolores
dc.contributor.authorRivero-Juárez, Antonio
dc.contributor.authorCarrero, Ana
dc.contributor.authorRíos, María José
dc.contributor.authorRuiz-Morales, Josefa
dc.contributor.authorGómez-Berrocal, Ana
dc.contributor.authorTéllez, Francisco
dc.contributor.authorDíaz-Menéndez, Marta
dc.contributor.authorCollado, Antonio
dc.contributor.authorPérez-Camacho, Inés
dc.contributor.authorDelgado-Fernández, Marcial
dc.contributor.authorVera-Méndez, Francisco
dc.contributor.authorPineda, Juan A.
dc.contributor.authoraffiliation[Neukam,K] Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain. [Espinosa,N] Service of Infectious Diseases, Hospital Universitario Virgen del Rocío,Seville, Spain. [Merino,D] Unit of Infectious Diseases, Complejo Hospitalario de Huelva, Huelva, Spain. [Rivero-Juárez,A] Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain. [Carrero,A] Unit of Infectious Diseases/HIV, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Ríos,MJ] Unit of Infectious Diseases, Hospital Virgen Macarena, Seville, Spain. [Ruiz-Morales,J] Unit of Infectious Diseases, Hospital Universitario Virgen de la Victoria, Malaga, Spain. [Gómez-Berrocal,A] Service of Internal Medicine/Infectious Diseases, Hospital Universitario de la Princesa, Madrid, Spain. [Téllez,F] CMU of Infectious Diseases and Microbiology, Hospital La Línea, AGS Campo de Gibraltar, La Linea de la Concepcion, Spain. [Díaz-Menéndez,M] Internal Medicine and Infectious Diseases, Hospital Universitario La Paz/IdiPAZ, Madrid, Spain. [Collado,A] Unit of Infectious Diseases, Hospital Torrecárdenas, Almeria, Spain. [Pérez-Camacho,I] Unit of Tropical Medicine, Hospital Poniente, El Ejido, Spain. [Delgado-Fernández,M] Service of Infectious Diseases, Hospital Regional de Málaga, Malaga, Spain. [Vera-Méndez,F] Section of Infectious Medicine, Hospital Universitario Santa Lucia, Cartagena, Spain. [Pineda,JA] Unit of Infectious Diseases, Hospital Universitario de Valme, Seville, Spain.es
dc.date.accessioned2016-11-18T13:13:30Z
dc.date.available2016-11-18T13:13:30Z
dc.date.issued2014-11-02
dc.description.abstractAlthough hepatotoxicity related to antiretroviral treatment (ART) has become less frequent, hepatotoxic events, such as transaminase elevations (TE), are still a matter of concern. RPV/FTC/TDF (EPA) is a new single tablet regimen which is widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV- coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low [1]. The aim of this ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE) during the first 48 weeks of EPA-based therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials.es
dc.description.versionYeses
dc.identifier.citationNeukam K, Espinosa N, Merino D, Rivero-Juárez A, Carrero A, Ríos Mj, et al. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study. J Int AIDS Soc.. 2014, 17(Suppl 3):19631es
dc.identifier.doi10.7448/IAS.17.4.19631
dc.identifier.essn1758-2652
dc.identifier.pmcPMC4224834
dc.identifier.pmid25394135
dc.identifier.urihttp://hdl.handle.net/10668/2533
dc.journal.titleJournal of the International AIDS Society
dc.language.isoen
dc.organizationAGS Campo de Gibraltar Oeste
dc.publisherBioMed Centrales
dc.relation.publisherversionhttp://www.jiasociety.org/index.php/jias/article/view/19631es
dc.rights.accessRightsopen access
dc.subjectBilirrubinaes
dc.subjectProtocolos clínicoses
dc.subjectCoinfecciónes
dc.subjectHepatitis Ces
dc.subjectCombinación emtricitabina, rilpivirina y tenofovires
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::Bilirubines
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocolses
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfectiones
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agentses
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis Ces
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studieses
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infectionses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidencees
dc.subject.meshMedical Subject Headings::Anatomy::Digestive System::Liveres
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitriles::RilpivirineEmtricitabine, Rilpivirine, Tenofovir Drug Combinationes
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Tabletses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminaseses
dc.titleHepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Studyes
dc.typeconference presentation
dc.type.hasVersionVoR
dspace.entity.typePublication

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