Publication: Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study
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Identifiers
Date
2014-11-02
Authors
Neukam, Karin
Espinosa, Nuria
Merino, Dolores
Rivero-Juárez, Antonio
Carrero, Ana
Ríos, María José
Ruiz-Morales, Josefa
Gómez-Berrocal, Ana
Téllez, Francisco
Díaz-Menéndez, Marta
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
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Abstract
Although hepatotoxicity related to antiretroviral treatment (ART) has become less frequent, hepatotoxic events,
such as transaminase elevations (TE), are still a matter of concern. RPV/FTC/TDF (EPA) is a new single tablet regimen which is
widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV-
coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low [1]. The aim of this
ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE) during the first 48 weeks of EPA-based
therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials.
Description
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::Bilirubin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfection
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents
Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitriles::RilpivirineEmtricitabine, Rilpivirine, Tenofovir Drug Combination
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Tablets
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfection
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents
Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitriles::RilpivirineEmtricitabine, Rilpivirine, Tenofovir Drug Combination
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Tablets
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases
DeCS Terms
CIE Terms
Keywords
Bilirrubina, Protocolos clínicos, Coinfección, Hepatitis C, Combinación emtricitabina, rilpivirina y tenofovir
Citation
Neukam K, Espinosa N, Merino D, Rivero-Juárez A, Carrero A, Ríos Mj, et al. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study. J Int AIDS Soc.. 2014, 17(Suppl 3):19631