Publication: Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma
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Date
2021
Authors
Lamback, Elisa B.
Henriques, Daniel G.
Vazquez-Borrego, Mari C.
de Azeredo Lima, Carlos H.
Kasuki, Leandro
Luque, Raul M.
Chimelli, Leila
Gadelha, Mônica R.
Advisors
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Volume Title
Publisher
Sociedade Brasileira de Endocrinologia e Metabologia
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Abstract
Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.
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MeSH Terms
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult
Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::Acromegaly
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neuroendocrine Tumors
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary Gland::Pituitary Gland, Anterior::Somatotrophs
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hyperplasia
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Apoplexy
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone-Releasing Hormones::Growth Hormone-Releasing Hormone
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography
Medical Subject Headings::Anatomy::Respiratory System::Lung
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult
Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::Acromegaly
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neuroendocrine Tumors
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary Gland::Pituitary Gland, Anterior::Somatotrophs
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hyperplasia
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Apoplexy
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone-Releasing Hormones::Growth Hormone-Releasing Hormone
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography
Medical Subject Headings::Anatomy::Respiratory System::Lung
DeCS Terms
CIE Terms
Keywords
Acromegaly, Pituitary adenoma, Neoplasias hipofisarias, Neuroendocrine tumors, Hyperplasia, Growth hormone-releasing hormone, Acromegalia, Tumores neuroendocrinos, Hiperplasia, Hormona liberadora de hormona del crecimiento
Citation
Lamback EB, Henriques DG, Vazquez-Borrego MC, de Azeredo Lima CH, Kasuki L, Luque RM, et al. Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma. Arch Endocrinol Metab. 2021 Oct 29;65(5):648-663