RT Journal Article
T1 Growth hormone-releasing  hormone-secreting pulmonary  neuroendocrine tumor associated  with pituitary hyperplasia  and somatotropinoma
A1 Lamback, Elisa B.
A1 Henriques, Daniel G.
A1 Vazquez-Borrego, Mari C.
A1 de Azeredo Lima, Carlos H.
A1 Kasuki, Leandro
A1 Luque, Raul M.
A1 Chimelli, Leila
A1 Gadelha, Mônica R.
K1 Acromegaly
K1 Pituitary adenoma
K1 Neoplasias hipofisarias
K1 Neuroendocrine tumors
K1 Hyperplasia
K1 Growth hormone-releasing hormone
K1 Acromegalia
K1 Tumores neuroendocrinos
K1 Hiperplasia
K1 Hormona liberadora de hormona del crecimiento
AB Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.
PB Sociedade Brasileira de Endocrinologia e Metabologia
SN 2359-3997
YR 2021
FD 2021
LK http://hdl.handle.net/10668/3912
UL http://hdl.handle.net/10668/3912
LA en
NO Lamback EB, Henriques DG, Vazquez-Borrego MC, de Azeredo Lima CH, Kasuki L, Luque RM, et al. Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma. Arch Endocrinol Metab. 2021 Oct 29;65(5):648-663
DS RISalud
RD Apr 8, 2025