Publication:
Standardized Map of Iodine Status in Europe.

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2020-07-15

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Ittermann, Till
Albrecht, Diana
Arohonka, Petra
Bilek, Radovan
de Castro, Joao J
Dahl, Lisbeth
Filipsson Nystrom, Helena
Gaberscek, Simona
Garcia-Fuentes, Eduardo
Gheorghiu, Monica L

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Abstract

Background: Knowledge about the population's iodine status is important, because it allows adjustment of iodine supply and prevention of iodine deficiency. The validity and comparability of iodine-related population studies can be improved by standardization, which was one of the goals of the EUthyroid project. The aim of this study was to establish the first standardized map of iodine status in Europe by using standardized urinary iodine concentration (UIC) data. Materials and Methods: We established a gold-standard laboratory in Helsinki measuring UIC by inductively coupled plasma mass spectrometry. A total of 40 studies from 23 European countries provided 75 urine samples covering the whole range of concentrations. Conversion formulas for UIC derived from the gold-standard values were established by linear regression models and were used to postharmonize the studies by standardizing the UIC data of the individual studies. Results: In comparison with the EUthyroid gold-standard, mean UIC measurements were higher in 11 laboratories and lower in 10 laboratories. The mean differences ranged from -36.6% to 49.5%. Of the 40 postharmonized studies providing data for the standardization, 16 were conducted in schoolchildren, 13 in adults, and 11 in pregnant women. Median standardized UIC was

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MeSH Terms

Algorithms
Child
Europe
Female
Finland
Food, Fortified
Geography
Humans
Iodine
Linear Models
Male
Mass Spectrometry
Nutritional Status
Pregnancy
Pregnant Women
Regression Analysis
Reproducibility of Results
Young Adult

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Keywords

epidemiology, iodine, iodine supply, method comparison

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