Publication: Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report.
Identifiers
Date
2006-08-28
Authors
Lucena González, María Isabel
Andrade Bellido, Raul Jesús
Vicioso Recio, Luis
González, F Jesús
Pachkoria, Ketevan
García-Muñoz, Beatriz
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Baishideng Publishing Group Co. Limited
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Abstract
Assigning causality in drug-induced liver injury is challenging particularly when more than one drug could be responsible. We report a woman on long-term therapy with raloxifen who developed acute cholestasis shortly after starting fenofibrate. The picture evolved into chronic cholestasis. We hypothesized that an interaction at the metabolic level could have triggered the presentation of hepatotoxicity after a very short time of exposure to fenofibrate in this patient. The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistence of toxic cholestasis.
Description
Case Reports; Journal Article; Research Support, Non-U.S. Gov't;
MeSH Terms
Medical Subject Headings::Diseases::Digestive System Diseases::Biliary Tract Diseases::Bile Duct Diseases::Cholestasis
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Butyrates::Isobutyrates::Fibric Acids::Fenofibrate
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzylidene Compounds::Stilbenes::Tamoxifen::Raloxifene
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Estrogen Receptor Modulators::Selective Estrogen Receptor Modulators
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Biopsy
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Butyrates::Isobutyrates::Fibric Acids::Fenofibrate
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzylidene Compounds::Stilbenes::Tamoxifen::Raloxifene
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Estrogen Receptor Modulators::Selective Estrogen Receptor Modulators
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Biopsy
DeCS Terms
CIE Terms
Keywords
Drug-drug Interactions, Hepatotoxicity, Causality Assessment, Colestasis, Fenofibrato, Hígado, Hipolipemiantes, Raloxifeno, Biopsia, Moduladores Selectivos de los Receptores de Estrógeno, Mediana edad, Humanos, Femenino
Citation
Lucena González MI, Andrade Bellido RJ, Vicioso Recio L, González FJ, Pachkoria K, García-Muñoz B. Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report. World J. Gastroenterol. 2006; 12(32):5244-6