RT Journal Article
T1 Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report.
A1 Lucena González, María Isabel
A1 Andrade Bellido, Raul Jesús
A1 Vicioso Recio, Luis
A1 González, F Jesús
A1 Pachkoria, Ketevan
A1 García-Muñoz, Beatriz
K1 Drug-drug Interactions
K1 Hepatotoxicity
K1 Causality Assessment
K1 Colestasis
K1 Fenofibrato
K1 Hígado
K1 Hipolipemiantes
K1 Raloxifeno
K1 Biopsia
K1 Moduladores Selectivos de los Receptores de Estrógeno
K1 Mediana edad
K1 Humanos
K1 Femenino
AB Assigning causality in drug-induced liver injury is challenging particularly when more than one drug could be responsible. We report a woman on long-term therapy with raloxifen who developed acute cholestasis shortly after starting fenofibrate. The picture evolved into chronic cholestasis. We hypothesized that an interaction at the metabolic level could have triggered the presentation of hepatotoxicity after a very short time of exposure to fenofibrate in this patient. The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistence of toxic cholestasis.
PB Baishideng Publishing Group Co. Limited
SN 1007-9327 (Print
YR 2006
FD 2006-08-28
LK http://hdl.handle.net/10668/822
UL http://hdl.handle.net/10668/822
LA en
NO Lucena González MI, Andrade Bellido RJ, Vicioso Recio L, González FJ, Pachkoria K, García-Muñoz B. Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report. World J. Gastroenterol. 2006; 12(32):5244-6
NO Case Reports; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025