Publication: A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers.
dc.contributor.author | Marrero, Ana Dacil | |
dc.contributor.author | Castilla, Laura | |
dc.contributor.author | Espartero, Jose L | |
dc.contributor.author | Madrona, Andres | |
dc.contributor.author | Quesada, Ana R | |
dc.contributor.author | Medina, Miguel Angel | |
dc.contributor.author | Martinez-Poveda, Beatriz | |
dc.date.accessioned | 2023-02-09T09:37:07Z | |
dc.date.available | 2023-02-09T09:37:07Z | |
dc.date.issued | 2020-12-15 | |
dc.description.abstract | The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenic potential of six synthetic hydroxytyrosyl alkyl ethers (HT C1, C2, C4, C6, C8 and C12). Our results showed that all compounds affected endothelial cell viability in vitro at low micromolar doses. In addition, compounds HT C1, C2, C4 and C6 inhibited endothelial cell migration and formation of tubular-like structures. In these assays, hydroxytyrosyl hexyl ether (HT C6) exhibited the most potent inhibitory activity in vitro, activating as well apoptosis in endothelial cells. Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in the chick chorioallantoic membrane assay. Hence, we present hydroxytyrosol synthetic derivative HT C6 as a new antiangiogenic compound and as a good candidate for an antiangiogenic drug in the treatment of angiogenesis-dependent diseases. | |
dc.description.version | Si | |
dc.identifier.citation | Marrero AD, Castilla L, Espartero JL, Madrona A, R Quesada A, Medina MÁ, et al. A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. Food Chem. 2020 Dec 15;333:127476. | |
dc.identifier.doi | 10.1016/j.foodchem.2020.127476 | |
dc.identifier.essn | 1873-7072 | |
dc.identifier.pmid | 32688305 | |
dc.identifier.unpaywallURL | https://riuma.uma.es/xmlui/bitstream/10630/19821/1/2020-07-05-MArrero%20et%20al-Article-Journal%20pre-proofs.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/15963 | |
dc.journal.title | Food chemistry | |
dc.journal.titleabbreviation | Food Chem | |
dc.language.iso | en | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 31 | |
dc.provenance | Realizada la curación de contenido 05/08/2025. | |
dc.publisher | Elsevier BV | |
dc.pubmedtype | Comparative Study | |
dc.pubmedtype | Journal Article | |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(20)31338-8 | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Angiogenesis | |
dc.subject | Apoptosis | |
dc.subject | Bovine aorta endothelial cells (BAEC) | |
dc.subject | Chorioallantoic membrane (CAM) assay | |
dc.subject | Hydroxytyrosyl alkyl ethers | |
dc.subject.decs | Fenoles | |
dc.subject.decs | Hidroxitirisol | |
dc.subject.decs | Éteres | |
dc.subject.decs | Inhibidores de la angiogénesis | |
dc.subject.decs | Células endoteliales | |
dc.subject.decs | Supervivencia celular | |
dc.subject.decs | Migración celular | |
dc.subject.mesh | Angiogenesis Inhibitors | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Aorta | |
dc.subject.mesh | Apoptosis | |
dc.subject.mesh | Endothelial Cells | |
dc.subject.mesh | Ethers | |
dc.subject.mesh | Olive Oil | |
dc.subject.mesh | Phenols | |
dc.subject.mesh | Phenylethyl Alcohol | |
dc.title | A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 333 | |
dspace.entity.type | Publication |
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