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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder.

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dc.contributor.authorHmadcha, Abdelkrim
dc.contributor.authorAguilera, Yolanda
dc.contributor.authorLozano-Arana, Maria Dolores
dc.contributor.authorMellado, Nuria
dc.contributor.authorSánchez, Javier
dc.contributor.authorMoya, Cristina
dc.contributor.authorSánchez-Palazón, Luis
dc.contributor.authorPalacios, Jose
dc.contributor.authorAntiñolo, Guillermo
dc.contributor.authorSoria, Bernat
dc.contributor.authoraffiliation[Hmadcha,A; Aguilera,Y; Mellado,N; Sánchez-Palazón,L; Soria,B] Department of Stem Cells, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Seville, Spain. [Hmadcha,A; Soria,B] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólica asociada (CIBERDEM), Madrid, Spain. [Lozano-Arana,MD; Sánchez,J; Moya,C; Antiñolo,G] Department of Genetics, Reproduction and Fetal Medicine, and [Palacios,J] Department of Pathology, Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Palacios,J] Department of Pathology, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Antiñolo,G] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spaines
dc.contributor.funderThis work was supported by a non-profit Foundation ‘Fundación Progreso y Salud’ of the Andalusian Regional Ministry of Health; Consejería de Economía y Conocimiento, Junta de Andalucía and Fondo Europeo de Desarrollo Regional (FEDER) (TCMR0021/06 and PI246-2008). Authors are supported by Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional (FEDER) (RD12/0019/0028 and RD012/0036/0017; PI10/00964; PI11/02923 and PI14/01015); the Ministry of Health and Consumer Affairs (Advanced Therapies Program Grant TRA-120).
dc.date.accessioned2016-07-04T09:29:49Z
dc.date.available2016-07-04T09:29:49Z
dc.date.issued2016-05
dc.descriptionLab resourcees
dc.description.abstractFrom 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B. Despite the translocation t(9;15)(q34.3;q14) detected in HVR2, all the 3 cell lines were characterised in vitro and in vivo as normal hESCs lines and were registered in the Spanish Stem Cell Bank.es
dc.description.versionYeses
dc.identifier.citationHmadcha A, Aguilera Y, Lozano-Arana MD, Mellado N, Sánchez J, Moya C, et al. Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder. Stem Cell Res. 2016;16(3):635-9es
dc.identifier.doi10.1016/j.scr.2016.03.012
dc.identifier.essn1876-7753
dc.identifier.issn1873-5061
dc.identifier.pmid27346196
dc.identifier.urihttp://hdl.handle.net/10668/2247
dc.journal.titleStem Cell Research
dc.language.isospa
dc.publisherElsevieres
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1873506116300101es
dc.rights.accessRightsopen access
dc.subjectCélulas madre embrionariases
dc.subjectFertilización in Vitroes
dc.subjectInvestigación básicaes
dc.subjectInvestigaciones con embrioneses
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Embryonic Stem Cells::Human Embryonic Stem Cellses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted::Fertilization in Vitroes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Obstetrical and Gynecological::Preimplantation Diagnosises
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Linees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Embryo Researches
dc.titleDerivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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