Publication: Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge.
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2021-09-03
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Safont, Belen
Tarraso, Julia
Rodriguez-Borja, Enrique
Fernández-Fabrellas, Estrella
Sancho-Chust, Jose N
Molina, Virginia
Lopez-Ramirez, Cecilia
Lope-Martinez, Amaia
Cabanes, Luis
Andreu, Ada Luz
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Abstract
Impairment in pulmonary function tests and radiological abnormalities are a major concern in COVID-19 survivors. Our aim is to evaluate functional respiratory parameters, changes in chest CT, and correlation with peripheral blood biomarkers involved in lung fibrosis at two and six months after SARS-CoV-2 pneumonia. COVID-FIBROTIC (clinicaltrials.gov NCT04409275) is a multicenter prospective observational cohort study aimed to evaluate discharged patients. Pulmonary function tests, circulating serum biomarkers, chest radiography and chest CT were performed at outpatient visits. In total, 313, aged 61.12 ± 12.26 years, out of 481 included patients were available. The proportion of patients with DLCO Almost half of patients with moderate or severe COVID-19 pneumonia had impaired pulmonary diffusion six months after discharge. Severe patients showed fibrotic lesions in CT scan and elevated serum biomarkers involved in pulmonary fibrosis.
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6-MWT, 6 minute-walk test, ARDS, acute respiratory distress syndrome, BMI, body mass index, COPD, chronic obstructive pulmonary disease, COVID-19 sequelae, COVID-19, coronavirus disease 2019, CT, computed tomography, Chest CT, DLCO, diffusing capacity for carbon monoxide, Fibrotic changes, GGO, ground-glass opacity, HFNC, high flow nasal cannula oxygen, ILD, interstitial lung disease, IMV, mechanical ventilation, Interstitial lung disease, Lung diffusion, MMP, matrix metalloproteinases, NIV, non-invasive ventilation, RALE, radiographic assessment of lung edema, RT-PCR, reverse transcriptase-polymerase chain reaction, SARS, severe acute respiratory syndrome, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Serum biomarkers, VEGF, vascular endothelial growth factor, mMRC, modified British Medical Research Council, sEGFR, soluble epidermal growth factor receptor