RT Journal Article T1 Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge. A1 Safont, Belen A1 Tarraso, Julia A1 Rodriguez-Borja, Enrique A1 Fernández-Fabrellas, Estrella A1 Sancho-Chust, Jose N A1 Molina, Virginia A1 Lopez-Ramirez, Cecilia A1 Lope-Martinez, Amaia A1 Cabanes, Luis A1 Andreu, Ada Luz A1 Herrera, Susana A1 Lahosa, Carolina A1 Ros, Jose Antonio A1 Rodriguez-Hermosa, Juan Luis A1 Soriano, Joan B A1 Moret-Tatay, Ines A1 Carbonell-Asins, Juan Antonio A1 Mulet, Alba A1 Signes-Costa, Jaime K1 6-MWT, 6 minute-walk test K1 ARDS, acute respiratory distress syndrome K1 BMI, body mass index K1 COPD, chronic obstructive pulmonary disease K1 COVID-19 sequelae K1 COVID-19, coronavirus disease 2019 K1 CT, computed tomography K1 Chest CT K1 DLCO, diffusing capacity for carbon monoxide K1 Fibrotic changes K1 GGO, ground-glass opacity K1 HFNC, high flow nasal cannula oxygen K1 ILD, interstitial lung disease K1 IMV, mechanical ventilation K1 Interstitial lung disease K1 Lung diffusion K1 MMP, matrix metalloproteinases K1 NIV, non-invasive ventilation K1 RALE, radiographic assessment of lung edema K1 RT-PCR, reverse transcriptase-polymerase chain reaction K1 SARS, severe acute respiratory syndrome K1 SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 K1 Serum biomarkers K1 VEGF, vascular endothelial growth factor K1 mMRC, modified British Medical Research Council K1 sEGFR, soluble epidermal growth factor receptor AB Impairment in pulmonary function tests and radiological abnormalities are a major concern in COVID-19 survivors. Our aim is to evaluate functional respiratory parameters, changes in chest CT, and correlation with peripheral blood biomarkers involved in lung fibrosis at two and six months after SARS-CoV-2 pneumonia. COVID-FIBROTIC (clinicaltrials.gov NCT04409275) is a multicenter prospective observational cohort study aimed to evaluate discharged patients. Pulmonary function tests, circulating serum biomarkers, chest radiography and chest CT were performed at outpatient visits. In total, 313, aged 61.12 ± 12.26 years, out of 481 included patients were available. The proportion of patients with DLCO  Almost half of patients with moderate or severe COVID-19 pneumonia had impaired pulmonary diffusion six months after discharge. Severe patients showed fibrotic lesions in CT scan and elevated serum biomarkers involved in pulmonary fibrosis. YR 2021 FD 2021-09-03 LK http://hdl.handle.net/10668/21998 UL http://hdl.handle.net/10668/21998 LA en DS RISalud RD Feb 15, 2025