Publication:
Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study

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Date

2023-10-18

Authors

Morelló-Vicente, Ana
Espejo-Martín, Marta
Oteiza-Rius, Inés
Antoñanzas, Javier
Velez Garcia-Nieto, Antonio

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MDPI
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Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is to compare the risk of local recurrence and metastases in patients with cSCC in highly sun-exposed areas compared to cSCC in less sun-exposed areas. Material and methods: A retrospective observational study was carried out, including 558 patients with histopathologically confirmed cSCC at the Reina Sofía University Hospital (HURS), Córdoba, during the period from 1 January 2017 to 31 December 2020. Demographic, clinical and anatomopathological data were collected. Results: Local recurrence occurs more often in highly sun-exposed areas (15.8%) compared to less sun-exposed ones (7.4%) (p < 0.05). However, no differences in the rate of metastases in both groups were found. The presence of affected surgical margins and tumor thickness were identified as independent risk factors for cSCC in low sun-exposure areas. Conclusions: cSCC located in anatomical areas of high sun exposure presented a greater risk of developing local recurrence in our population, which could suggest that these tumors have worse prognosis than those that lie in areas that do not receive chronic sun exposure.

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MeSH Terms

Humans
Carcinoma Squamous Cell
Skin Neoplasms
Incidence
Margins of Excision
Prognosis
Sunlight
Risk Factors
Hospitals

DeCS Terms

Carcinoma de células escamosas
Factores de riesgo
Demografía
Factores de riesgo
Hospitales
Metástasis de la neoplasia

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Keywords

Cutaneous squamous cell carcinoma, Local recurrence, Metastases, Sun exposure, Carcinoma de células escamosas, Metástasis de la neoplasia

Citation

Morelló-Vicente A, Espejo-Marín M, Oteiza-Rius I, Antoñanzas J, Vélez A, Salido-Vallejo R. Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study. Cancers. 2023 Oct 18;15(20):5037