RT Journal Article
T1 Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study
A1 Morelló-Vicente, Ana
A1 Espejo-Martín, Marta
A1 Oteiza-Rius, Inés
A1 Antoñanzas, Javier
A1 Velez Garcia-Nieto, Antonio
A1 Salido-Vallejo, Rafael
K1 Cutaneous squamous cell carcinoma
K1 Local recurrence
K1 Metastases
K1 Sun exposure
K1 Carcinoma de células escamosas
K1 Metástasis de la neoplasia
AB Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is to compare the risk of local recurrence and metastases in patients with cSCC in highly sun-exposed areas compared to cSCC in less sun-exposed areas. Material and methods: A retrospective observational study was carried out, including 558 patients with histopathologicallyconfirmed cSCC at the Reina Sofía University Hospital (HURS), Córdoba, during the period from 1 January 2017 to 31 December 2020. Demographic, clinical and anatomopathological data were collected. Results: Local recurrence occurs more often in highly sun-exposed areas (15.8%) compared to less sun-exposed ones (7.4%) (p < 0.05). However, no differences in the rate of metastases in both groups were found. The presence of affected surgical margins and tumor thickness were identified as independent risk factors for cSCC in low sun-exposure areas. Conclusions: cSCC located in anatomical areas of high sun exposure presented a greater risk of developing local recurrence in our population, which could suggest that these tumors have worse prognosis than those that lie in areas that do not receive chronic sun exposure.
PB MDPI
SN 2072-6694
YR 2023
FD 2023-10-18
LK https://hdl.handle.net/10668/23204
UL https://hdl.handle.net/10668/23204
LA en
NO Morelló-Vicente A, Espejo-Marín M, Oteiza-Rius I, Antoñanzas J, Vélez A, Salido-Vallejo R. Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study. Cancers. 2023 Oct 18;15(20):5037
DS RISalud
RD Apr 18, 2025