Publication:
Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.

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Date

2020-06-29

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Uribarri, Aitor
Núñez-Gil, Iván J
Aparisi, Alvaro
Becerra-Muñoz, Victor M
Feltes, Gisela
Trabattoni, Daniela
Fernández-Rozas, Inmaculada
Viana-Llamas, María C
Pepe, Martino
Cerrato, Enrico

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Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain. Analysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m2, eGFR 30-60 mL/min/1.73 m2 and eGFR  60 mL/min/1.73 m2, eGFR 30-60 mL/min/1.73 m2 and eGFR  758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR  60 vs eGFR 30-60 vs and eGFR  Renal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings.

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MeSH Terms

Acute Kidney Injury
Aged
Aged, 80 and over
Angiotensin-Converting Enzyme 2
Betacoronavirus
COVID-19
Coronavirus Infections
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Registries
Risk Assessment
SARS-CoV-2

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Keywords

Acute kidney injury, COVID-19, Chronic kidney failure, Mortality, Prognosis, Registry

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