Publication: Modelling Particle Transport and Deposition in the Human Healthy and Stented Tracheobronchial Airways.
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Date
2020-03-25
Authors
Malvè, M
Sánchez-Matás, C
López-Villalobos, J L
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Abstract
The main goal of this study is the quantification of the particle transport and deposition within the human airways during light, normal and exercise breathing conditions using the computational fluid dynamics. In particular we presented a comparison between healthy and stented airways. The considered tracheobronchial model is based on the Weibel symmetric model in which we have inserted the Dumon prosthesis at different locations and on the CT-based geometries of a healthy and a stented airway. The results indicate an important redistribution of the particle deposition locations. Local overdoses can be found in the proximal regions of the prostheses, independently of the breathing conditions, of the particle size and of the considered geometry. The presented work is aimed to contribute to the understanding of the particle deposition in the human lung and to improve drug-aerosol therapies. For patients that underwent airways reconstructive surgery, it can give detailed information about the deposition efficiency and it may help targeting specific airways regions.
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MeSH Terms
Adult
Aerosols
Humans
Hydrodynamics
Models, Biological
Patient-Specific Modeling
Respiratory Physiological Phenomena
Respiratory System
Stents
Aerosols
Humans
Hydrodynamics
Models, Biological
Patient-Specific Modeling
Respiratory Physiological Phenomena
Respiratory System
Stents
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Keywords
Breathing conditions, Computational fluid dynamics, Computerized tomography, Endoprosthesis, Particle deposition, Tracheobronchial airways