RT Journal Article
T1 Modelling Particle Transport and Deposition in the Human Healthy and Stented Tracheobronchial Airways.
A1 Malvè, M
A1 Sánchez-Matás, C
A1 López-Villalobos, J L
K1 Breathing conditions
K1 Computational fluid dynamics
K1 Computerized tomography
K1 Endoprosthesis
K1 Particle deposition
K1 Tracheobronchial airways
AB The main goal of this study is the quantification of the particle transport and deposition within the human airways during light, normal and exercise breathing conditions using the computational fluid dynamics. In particular we presented a comparison between healthy and stented airways. The considered tracheobronchial model is based on the Weibel symmetric model in which we have inserted the Dumon prosthesis at different locations and on the CT-based geometries of a healthy and a stented airway. The results indicate an important redistribution of the particle deposition locations. Local overdoses can be found in the proximal regions of the prostheses, independently of the breathing conditions, of the particle size and of the considered geometry. The presented work is aimed to contribute to the understanding of the particle deposition in the human lung and to improve drug-aerosol therapies. For patients that underwent airways reconstructive surgery, it can give detailed information about the deposition efficiency and it may help targeting specific airways regions.
YR 2020
FD 2020-03-25
LK http://hdl.handle.net/10668/15287
UL http://hdl.handle.net/10668/15287
LA en
DS RISalud
RD Jul 30, 2025