Publication:
Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy.

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Date

2017-10-28

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Villatoro, Antonio J
Fernández, Viviana
Claros, Silvia
Alcoholado, Cristina
Cifuentes, Manuel
Merayo-Lloves, Jesús
Andrades, José A
Becerra, José

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Abstract

Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology.

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Animals
Cell- and Tissue-Based Therapy
Dry Eye Syndromes
Humans
Intercellular Signaling Peptides and Proteins
Regenerative Medicine
Stem Cell Transplantation
Stem Cells

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Keywords

allogenic cell therapy, dry eye, growth factor, keratoconjunctivitis sicca, lacrimal gland, mesenchymal stem cell, regenerative medicine

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