Publication: Incidence, clinical, risk factors and outcomes of Guillain-Barré in Covid-19.
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Identifiers
Date
2020-12-09
Authors
Fragiel, Marcos
Miro, Oscar
Llorens, Pere
Jimenez, Sonia
Piñera, Pascual
Burillo, Guillermo
Martin, Alfonso
Martin-Sanchez, Francisco J
Garcia-Lamberechts, Eric J
Jacob, Javier
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
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Abstract
We diagnosed 11 Guillain-Barré syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (EDs) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15‰) than non-COVID (0.02‰) patients (odds ratio [OR] = 6.30, 95% confidence interval [CI] = 3.18-12.5), as was the standardized incidence (9.44 and 0.69 cases/100,000 inhabitant-years, respectively, OR = 13.5, 95% CI = 9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR = 27.59, 95% CI = 1.296-587) and COVID-non-GBS (OR = 7.875, 95% CI = 1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. ANN NEUROL 2021;89:598-603.
Description
MeSH Terms
Immunoglobulins, Intravenous
Immunologic Factors
Incidence
Intensive Care Units
Length of Stay
Male
Middle Aged
Olfaction Disorders
Risk Factors
SARS-CoV-2
Spain
Taste Disorders
Immunologic Factors
Incidence
Intensive Care Units
Length of Stay
Male
Middle Aged
Olfaction Disorders
Risk Factors
SARS-CoV-2
Spain
Taste Disorders
DeCS Terms
España
Factores inmunológicos
Factores de riesgo
Incidencia
Inmunoglobulinas intravenosas
Masculino
Tiempo de internación
Trastornos del gusto
Trastornos del olfato
Unidades de cuidados intensivos
Factores inmunológicos
Factores de riesgo
Incidencia
Inmunoglobulinas intravenosas
Masculino
Tiempo de internación
Trastornos del gusto
Trastornos del olfato
Unidades de cuidados intensivos
CIE Terms
Keywords
Adult, Aged, COVID-19, Case-Control Studies, Female, Guillain-Barre Syndrome, Hospital Mortality, Humans
Citation
Fragiel M, Miró Ò, Llorens P, Jiménez S, Piñera P, Burillo G, et al. Incidence, clinical, risk factors and outcomes of Guillain-Barré in Covid-19. Ann Neurol. 2021 Mar;89(3):598-603.