Publication: Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature
dc.contributor.author | Silva-Fernandez, Lucia | |
dc.contributor.author | Oton, Teresa | |
dc.contributor.author | Askanase, Anca | |
dc.contributor.author | Carreira, Patricia | |
dc.contributor.author | Lopez-Longo, Francisco Javier | |
dc.contributor.author | Olive, Alejandro | |
dc.contributor.author | Rua-Figueroa, Inigo | |
dc.contributor.author | Narvaez, Javier | |
dc.contributor.author | Ruiz-Lucea, Esther | |
dc.contributor.author | Andres, Mariano | |
dc.contributor.author | Calvo, Enrique | |
dc.contributor.author | Toyos, Francisco | |
dc.contributor.author | Alegre-Sancho, Juan Jose | |
dc.contributor.author | Tomero, Eva | |
dc.contributor.author | Montilla, Carlos | |
dc.contributor.author | Zea, Antonio | |
dc.contributor.author | Uriarte, Esther | |
dc.contributor.author | Calvo-Alen, Jaime | |
dc.contributor.author | Marras, Carlos | |
dc.contributor.author | Martinez-Taboada, Victor M. | |
dc.contributor.author | Belmonte-Lopez, Maria Angeles | |
dc.contributor.author | Rosas, Jose | |
dc.contributor.author | Raya, Enrique | |
dc.contributor.author | Bonilla, Gema | |
dc.contributor.author | Freire, Mercedes | |
dc.contributor.author | Pego-Reigosa, Jose Maria | |
dc.contributor.author | Millan, Isabel | |
dc.contributor.author | Hughes-Morley, Adwoa | |
dc.contributor.author | Andreu, Jose Luis | |
dc.contributor.authoraffiliation | [Silva-Fernandez, Lucia] Complexo Hosp Univ Ferrol, Serv Reumatol, Ferrol, A Coruna, Spain | |
dc.contributor.authoraffiliation | [Oton, Teresa] Inst Salud Musculoesquelet, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Askanase, Anca] Hosp Joint Dis & Med Ctr, Rheumatol Dept, New York, NY USA | |
dc.contributor.authoraffiliation | [Carreira, Patricia] Hosp Univ 12 Octubre, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Javier Lopez-Longo, Francisco] Hosp Gen Univ Gregorio Maranon, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Olive, Alejandro] Hosp Badalona Germans Trias & Pujol, Serv Reumatol, Barcelona, Spain | |
dc.contributor.authoraffiliation | [Rua-Figueroa, Inigo] Hosp Univ Doctor Negrin, Serv Reumatol, Las Palmas Gran Canaria, Spain | |
dc.contributor.authoraffiliation | [Narvaez, Javier] Hosp Univ Bellvitge, Serv Reumatol, Barcelona, Spain | |
dc.contributor.authoraffiliation | [Ruiz-Lucea, Esther] Hosp Basurto, Serv Reumatol, Bilbao, Spain | |
dc.contributor.authoraffiliation | [Andres, Mariano] Hosp Gen Univ Alicante, Serv Reumatol, Alicante, Spain | |
dc.contributor.authoraffiliation | [Calvo, Enrique] Hosp Univ Infanta Sofia, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Toyos, Francisco] Hosp Univ Virgen Macarena, Serv Reumatol, Seville, Spain | |
dc.contributor.authoraffiliation | [Jose Alegre-Sancho, Juan] Hosp Univ Doctor Peset, Serv Reumatol, Valencia, Spain | |
dc.contributor.authoraffiliation | [Tomero, Eva] Hosp Univ La Princesa, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Montilla, Carlos] Hosp Univ Salamanca, Serv Reumatol, Salamanca, Spain | |
dc.contributor.authoraffiliation | [Zea, Antonio] Hosp Univ Ramon y Cajal, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Uriarte, Esther] Hosp Univ Donostia, Serv Reumatol, San Sebastian, Spain | |
dc.contributor.authoraffiliation | [Calvo-Alen, Jaime] Hosp Sienallana, Serv Reumatol, Torrelavega, Cantabria, Spain | |
dc.contributor.authoraffiliation | [Marras, Carlos] Hosp Univ Virgen Arrixaca, Serv Reumatol, Murcia, Spain | |
dc.contributor.authoraffiliation | [Martinez-Taboada, Victor M.] Hosp Univ Marques Valdecilla, Serv Reumatol, Santander, Spain | |
dc.contributor.authoraffiliation | [Angeles Belmonte-Lopez, Maria] Hosp Univ Carlos Haya, Serv Reumatol, Unidad Invest, Malaga, Spain | |
dc.contributor.authoraffiliation | [Rosas, Jose] Hosp Marina Baixa Villajoyosa, Serv Reumatol, Alicante, Spain | |
dc.contributor.authoraffiliation | [Raya, Enrique] Hosp Univ San Cecilio, Serv Reumatol, Granada, Spain | |
dc.contributor.authoraffiliation | [Bonilla, Gema] Hosp Univ La Paz, Serv Reumatol, Madrid, Spain | |
dc.contributor.authoraffiliation | [Freire, Mercedes] Complejo Hosp Univ A Coruna, Serv Reumatol, La Coruna, Spain | |
dc.contributor.authoraffiliation | [Maria Pego-Reigosa, Jose] Complexo Hosp Univ Vigo, Serv Reumatol, Vigo, Pontevedra, Spain | |
dc.contributor.authoraffiliation | [Millan, Isabel] Hosp Univ Puerta Hierro Majadahonda, Dept Bioestadist, Madrid, Spain | |
dc.contributor.authoraffiliation | [Hughes-Morley, Adwoa] Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England | |
dc.contributor.authoraffiliation | [Andreu, Jose Luis] Hosp Univ Puerta Hierro Majadahonda, Serv Reumatol, Madrid, Spain | |
dc.contributor.group | Spanish Soc Rheumatology Syst | |
dc.date.accessioned | 2023-02-12T02:21:08Z | |
dc.date.available | 2023-02-12T02:21:08Z | |
dc.date.issued | 2019-01-01 | |
dc.description.abstract | Objectives: The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN.Methods: We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA.Results: Mean age was 34.2 +/- 12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98 +/- 0.78 mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24 h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death.Conclusions: Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis. | |
dc.description.abstract | Objetivos: Los conocimientos sobre el curso y el desenlace a largo plazo de la nefritis lúpica membranosa (NLM) pura son todavía escasos. El objetivo de este estudio es evaluar las características clínicas, curso, desenlace e indicadores pronósticos de la NLM y determinar el impacto de la etnicidad y tipo de cobertura sanitaria en el curso y pronóstico de la NLM. Métodos: Se realizó una revisión retrospectiva de las historias de 150 pacientes con NLM de Espa˜ na y Estados Unidos. Resultados: La edad media fue 34,2 ± 12,5 y el 80% eran mujeres. El 68% de los pacientes tenían síndrome nefrótico al diagnóstico. La creatinina sérica media fue 0,98 ± 0,78 mg/dl. El 6% de los pacientes fallecieron y el 5,3% desarrollaron insuficiencia renal terminal (IRT). El sexo masculino, la hipertensión, la dislipemia, la alta proteinuria basal, la alta creatininemia y un aclaramiento de creatinina reducido predijeron el desarrollo de IRT. La edad, la insuficiencia cardíaca, la arteriopatía periférica, la hemodiálisis y el no haber recibido micofenolato de mofetilo o antimaláricos predijeron el fallecimiento. Conclusiones: La NLM pura suele debutar con síndrome nefrótico, alta proteinuria y creatininemia normal. Su pronóstico es favourable en términos de mantenimiento de la función renal aunque la proteinuria habitualmente persiste durante el seguimiento. La enfermedad cardiovascular basal y no tener cobertura sanitaria se relacionan con mal pronóstico. | |
dc.description.version | Si | |
dc.identifier.citation | Silva-Fernández L, Otón T, Askanase A, Carreira P, López-Longo FJ, Olivé A, et al. Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature. Reumatol Clin (Engl Ed). 2019 Jan-Feb;15(1):34-42. English, Spanish | |
dc.identifier.doi | 10.1016/j.reuma.2017.04.005 | |
dc.identifier.essn | 1885-1398 | |
dc.identifier.issn | 1699-258X | |
dc.identifier.unpaywallURL | https://eprints.whiterose.ac.uk/117215/1/Silva_Fernandez_2017_Pure_Membranous_Lupus_Nephritis_Description_of_a_Cohort_of_150_patients.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/18876 | |
dc.identifier.wosID | 455449600005 | |
dc.issue.number | 1 | |
dc.journal.title | Reumatologia clinica | |
dc.journal.titleabbreviation | Reumatol. clin. | |
dc.language.iso | en | |
dc.organization | Hospital Universitario San Cecilio | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Hospital Universitario Virgen Macarena | |
dc.page.number | 34-42 | |
dc.provenance | Realizada la curación de contenido 06/05/2025 | |
dc.publisher | Elsevier | |
dc.relation.publisherversion | http://www.elsevier.es/en/linksolver/pdf/pii/S1699-258X(17)30096-7 | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Systemic lupus erythematosus | |
dc.subject | Membranous glomerulonephritis | |
dc.subject | Retrospective review | |
dc.subject | Lupus eritematoso sistémico | |
dc.subject | Glomerulonefritis membranosa | |
dc.subject | Estudio retrospectivo | |
dc.subject.decs | Creatinina | |
dc.subject.decs | Proteinuria | |
dc.subject.decs | Fallo renal crónico | |
dc.subject.decs | Suero | |
dc.subject.decs | Síndrome nefrótico | |
dc.subject.decs | Diálisis renal | |
dc.subject.decs | Enfermedades cardiovasculares | |
dc.subject.mesh | Mycophenolate-mofetil | |
dc.subject.mesh | Cardiovascular-disease | |
dc.subject.mesh | Revised criteria | |
dc.subject.mesh | Chinese patients | |
dc.subject.mesh | Erythematosus | |
dc.subject.mesh | Nephropathy | |
dc.subject.mesh | Cyclophosphamide | |
dc.subject.mesh | Azathioprine | |
dc.subject.mesh | Tacrolimus | |
dc.title | Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature | |
dc.title.alternative | Nefritis lúpica membranosa pura: descripción de una cohorte de 150 pacientes y revisión de la literatura | |
dc.type | review | |
dc.type.hasVersion | AM | |
dc.volume.number | 15 | |
dc.wostype | Review | |
dspace.entity.type | Publication |
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