Publication:
Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature

dc.contributor.authorSilva-Fernandez, Lucia
dc.contributor.authorOton, Teresa
dc.contributor.authorAskanase, Anca
dc.contributor.authorCarreira, Patricia
dc.contributor.authorLopez-Longo, Francisco Javier
dc.contributor.authorOlive, Alejandro
dc.contributor.authorRua-Figueroa, Inigo
dc.contributor.authorNarvaez, Javier
dc.contributor.authorRuiz-Lucea, Esther
dc.contributor.authorAndres, Mariano
dc.contributor.authorCalvo, Enrique
dc.contributor.authorToyos, Francisco
dc.contributor.authorAlegre-Sancho, Juan Jose
dc.contributor.authorTomero, Eva
dc.contributor.authorMontilla, Carlos
dc.contributor.authorZea, Antonio
dc.contributor.authorUriarte, Esther
dc.contributor.authorCalvo-Alen, Jaime
dc.contributor.authorMarras, Carlos
dc.contributor.authorMartinez-Taboada, Victor M.
dc.contributor.authorBelmonte-Lopez, Maria Angeles
dc.contributor.authorRosas, Jose
dc.contributor.authorRaya, Enrique
dc.contributor.authorBonilla, Gema
dc.contributor.authorFreire, Mercedes
dc.contributor.authorPego-Reigosa, Jose Maria
dc.contributor.authorMillan, Isabel
dc.contributor.authorHughes-Morley, Adwoa
dc.contributor.authorAndreu, Jose Luis
dc.contributor.authoraffiliation[Silva-Fernandez, Lucia] Complexo Hosp Univ Ferrol, Serv Reumatol, Ferrol, A Coruna, Spain
dc.contributor.authoraffiliation[Oton, Teresa] Inst Salud Musculoesquelet, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Askanase, Anca] Hosp Joint Dis & Med Ctr, Rheumatol Dept, New York, NY USA
dc.contributor.authoraffiliation[Carreira, Patricia] Hosp Univ 12 Octubre, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Javier Lopez-Longo, Francisco] Hosp Gen Univ Gregorio Maranon, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Olive, Alejandro] Hosp Badalona Germans Trias & Pujol, Serv Reumatol, Barcelona, Spain
dc.contributor.authoraffiliation[Rua-Figueroa, Inigo] Hosp Univ Doctor Negrin, Serv Reumatol, Las Palmas Gran Canaria, Spain
dc.contributor.authoraffiliation[Narvaez, Javier] Hosp Univ Bellvitge, Serv Reumatol, Barcelona, Spain
dc.contributor.authoraffiliation[Ruiz-Lucea, Esther] Hosp Basurto, Serv Reumatol, Bilbao, Spain
dc.contributor.authoraffiliation[Andres, Mariano] Hosp Gen Univ Alicante, Serv Reumatol, Alicante, Spain
dc.contributor.authoraffiliation[Calvo, Enrique] Hosp Univ Infanta Sofia, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Toyos, Francisco] Hosp Univ Virgen Macarena, Serv Reumatol, Seville, Spain
dc.contributor.authoraffiliation[Jose Alegre-Sancho, Juan] Hosp Univ Doctor Peset, Serv Reumatol, Valencia, Spain
dc.contributor.authoraffiliation[Tomero, Eva] Hosp Univ La Princesa, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Montilla, Carlos] Hosp Univ Salamanca, Serv Reumatol, Salamanca, Spain
dc.contributor.authoraffiliation[Zea, Antonio] Hosp Univ Ramon y Cajal, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Uriarte, Esther] Hosp Univ Donostia, Serv Reumatol, San Sebastian, Spain
dc.contributor.authoraffiliation[Calvo-Alen, Jaime] Hosp Sienallana, Serv Reumatol, Torrelavega, Cantabria, Spain
dc.contributor.authoraffiliation[Marras, Carlos] Hosp Univ Virgen Arrixaca, Serv Reumatol, Murcia, Spain
dc.contributor.authoraffiliation[Martinez-Taboada, Victor M.] Hosp Univ Marques Valdecilla, Serv Reumatol, Santander, Spain
dc.contributor.authoraffiliation[Angeles Belmonte-Lopez, Maria] Hosp Univ Carlos Haya, Serv Reumatol, Unidad Invest, Malaga, Spain
dc.contributor.authoraffiliation[Rosas, Jose] Hosp Marina Baixa Villajoyosa, Serv Reumatol, Alicante, Spain
dc.contributor.authoraffiliation[Raya, Enrique] Hosp Univ San Cecilio, Serv Reumatol, Granada, Spain
dc.contributor.authoraffiliation[Bonilla, Gema] Hosp Univ La Paz, Serv Reumatol, Madrid, Spain
dc.contributor.authoraffiliation[Freire, Mercedes] Complejo Hosp Univ A Coruna, Serv Reumatol, La Coruna, Spain
dc.contributor.authoraffiliation[Maria Pego-Reigosa, Jose] Complexo Hosp Univ Vigo, Serv Reumatol, Vigo, Pontevedra, Spain
dc.contributor.authoraffiliation[Millan, Isabel] Hosp Univ Puerta Hierro Majadahonda, Dept Bioestadist, Madrid, Spain
dc.contributor.authoraffiliation[Hughes-Morley, Adwoa] Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England
dc.contributor.authoraffiliation[Andreu, Jose Luis] Hosp Univ Puerta Hierro Majadahonda, Serv Reumatol, Madrid, Spain
dc.contributor.groupSpanish Soc Rheumatology Syst
dc.date.accessioned2023-02-12T02:21:08Z
dc.date.available2023-02-12T02:21:08Z
dc.date.issued2019-01-01
dc.description.abstractObjectives: The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN.Methods: We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA.Results: Mean age was 34.2 +/- 12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98 +/- 0.78 mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24 h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death.Conclusions: Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis.
dc.description.abstractObjetivos: Los conocimientos sobre el curso y el desenlace a largo plazo de la nefritis lúpica membranosa (NLM) pura son todavía escasos. El objetivo de este estudio es evaluar las características clínicas, curso, desenlace e indicadores pronósticos de la NLM y determinar el impacto de la etnicidad y tipo de cobertura sanitaria en el curso y pronóstico de la NLM. Métodos: Se realizó una revisión retrospectiva de las historias de 150 pacientes con NLM de Espa˜ na y Estados Unidos. Resultados: La edad media fue 34,2 ± 12,5 y el 80% eran mujeres. El 68% de los pacientes tenían síndrome nefrótico al diagnóstico. La creatinina sérica media fue 0,98 ± 0,78 mg/dl. El 6% de los pacientes fallecieron y el 5,3% desarrollaron insuficiencia renal terminal (IRT). El sexo masculino, la hipertensión, la dislipemia, la alta proteinuria basal, la alta creatininemia y un aclaramiento de creatinina reducido predijeron el desarrollo de IRT. La edad, la insuficiencia cardíaca, la arteriopatía periférica, la hemodiálisis y el no haber recibido micofenolato de mofetilo o antimaláricos predijeron el fallecimiento. Conclusiones: La NLM pura suele debutar con síndrome nefrótico, alta proteinuria y creatininemia normal. Su pronóstico es favourable en términos de mantenimiento de la función renal aunque la proteinuria habitualmente persiste durante el seguimiento. La enfermedad cardiovascular basal y no tener cobertura sanitaria se relacionan con mal pronóstico.
dc.description.versionSi
dc.identifier.citationSilva-Fernández L, Otón T, Askanase A, Carreira P, López-Longo FJ, Olivé A, et al. Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature. Reumatol Clin (Engl Ed). 2019 Jan-Feb;15(1):34-42. English, Spanish
dc.identifier.doi10.1016/j.reuma.2017.04.005
dc.identifier.essn1885-1398
dc.identifier.issn1699-258X
dc.identifier.unpaywallURLhttps://eprints.whiterose.ac.uk/117215/1/Silva_Fernandez_2017_Pure_Membranous_Lupus_Nephritis_Description_of_a_Cohort_of_150_patients.pdf
dc.identifier.urihttp://hdl.handle.net/10668/18876
dc.identifier.wosID455449600005
dc.issue.number1
dc.journal.titleReumatologia clinica
dc.journal.titleabbreviationReumatol. clin.
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Regional de Málaga
dc.organizationHospital Universitario Virgen Macarena
dc.page.number34-42
dc.provenanceRealizada la curación de contenido 06/05/2025
dc.publisherElsevier
dc.relation.publisherversionhttp://www.elsevier.es/en/linksolver/pdf/pii/S1699-258X(17)30096-7
dc.rights.accessRightsRestricted Access
dc.subjectSystemic lupus erythematosus
dc.subjectMembranous glomerulonephritis
dc.subjectRetrospective review
dc.subjectLupus eritematoso sistémico
dc.subjectGlomerulonefritis membranosa
dc.subjectEstudio retrospectivo
dc.subject.decsCreatinina
dc.subject.decsProteinuria
dc.subject.decsFallo renal crónico
dc.subject.decsSuero
dc.subject.decsSíndrome nefrótico
dc.subject.decsDiálisis renal
dc.subject.decsEnfermedades cardiovasculares
dc.subject.meshMycophenolate-mofetil
dc.subject.meshCardiovascular-disease
dc.subject.meshRevised criteria
dc.subject.meshChinese patients
dc.subject.meshErythematosus
dc.subject.meshNephropathy
dc.subject.meshCyclophosphamide
dc.subject.meshAzathioprine
dc.subject.meshTacrolimus
dc.titlePure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature
dc.title.alternativeNefritis lúpica membranosa pura: descripción de una cohorte de 150 pacientes y revisión de la literatura
dc.typereview
dc.type.hasVersionAM
dc.volume.number15
dc.wostypeReview
dspace.entity.typePublication

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