Publication: Inmunopatología de la esclerosis múltiple.
Loading...
Identifiers
Date
2014
Authors
Quintana, Francisco J.
Pérez-Sánchez, Soledad
Farez, Mauricio F.
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Fundación Revista Medicina
Metrics
Export
Abstract
La esclerosis múltiple es una enfermedad inflamatoria desmielinizante que afecta el sistema nervioso central y que es considerada una de las principales causas de discapacidad en jóvenes adultos. Las causas de la esclerosis múltiple son aún desconocidas, aunque se cree que una combinación de factores genéticos y ambientales resulta en una respuesta autoinmune que promueve la degeneración neuronal/axonal. En esta revisión se analiza la asociación entre la respuesta inmune y la neurodegeneración en la esclerosis múltiple.
Multiple sclerosis is an inflammatory demyelinating disease affecting the central nervous system and considered one of the leading causes of disability in young adults. The precise cause of multiple sclerosis is unknown, although the current evidence points towards a combination of genetic and environmental factors leading to an autoimmune response that promotes neuronal degeneration. In this review, we will describe the association between the immune response and neurodegeneration in multiple sclerosis.
Multiple sclerosis is an inflammatory demyelinating disease affecting the central nervous system and considered one of the leading causes of disability in young adults. The precise cause of multiple sclerosis is unknown, although the current evidence points towards a combination of genetic and environmental factors leading to an autoimmune response that promotes neuronal degeneration. In this review, we will describe the association between the immune response and neurodegeneration in multiple sclerosis.
Description
English Abstract; Journal Article; Review;
MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Oligodendroglia::Myelin Sheath
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Nerve Degeneration
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
Medical Subject Headings::Anatomy::Nervous System::Neuroglia
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxic
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Antibody-Producing Cells::B-Lymphocytes
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Oligodendroglia::Myelin Sheath
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Nerve Degeneration
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
Medical Subject Headings::Anatomy::Nervous System::Neuroglia
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxic
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Antibody-Producing Cells::B-Lymphocytes
DeCS Terms
CIE Terms
Keywords
Multiple sclerosis, Pathogenesis, Esclerosis múltiple, Patogénesis, Enfermedades neurodegenerativas, Inmunidad celular, Vaina de mielina
Citation
Quintana FJ, Pérez-Sánchez S, Farez MF. Inmunopatología de la esclerosis múltiple. Medicina (B Aires). 2014; 74(5):404-10