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Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study.

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dc.contributor.authorRodriguez-Gonzalez, Moises
dc.contributor.authorCastellano-Martinez, Ana
dc.contributor.authorEstalella-Mendoza, Ana
dc.contributor.authorRodriguez-Campoy, Patricia
dc.contributor.authorEstepa-Pedregosa, Lorena
dc.contributor.authorCalero-Ruiz, Maria Mercedes
dc.contributor.authorSaez-Benito Godino, Ana
dc.contributor.authorFlores-Gonzalez, Jose Carlos
dc.date.accessioned2023-05-03T15:16:22Z
dc.date.available2023-05-03T15:16:22Z
dc.date.issued2022-10-22
dc.description.abstractWe aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis. A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann-Whitney U test, Spearman's correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis. Seventeen infants (median age 68 [IQR: 36-91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman's ρ = 0.81 & R2  coefficient = 0.751; p  The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting.
dc.description.versionSi
dc.identifier.citationRodríguez-González M, Castellano-Martínez A, Estalella-Mendoza A, Rodríguez-Campoy P, Estepa-Pedregosa L, Calero-Ruiz MM, et al. Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study. Pediatr Pulmonol. 2023 Feb;58(2):492-499
dc.identifier.doi10.1002/ppul.26215
dc.identifier.essn1099-0496
dc.identifier.pmid36314349
dc.identifier.unpaywallURLhttps://doi.org/10.22541/au.165702067.78363345/v1
dc.identifier.urihttp://hdl.handle.net/10668/22495
dc.issue.number2
dc.journal.titlePediatric pulmonology
dc.journal.titleabbreviationPediatr Pulmonol
dc.language.isoen
dc.organizationHospital Universitario Puerta del Mar
dc.organizationInstituto de Investigación e Innovación en Ciencias Biomédicas
dc.page.number492-499
dc.publisherWiley
dc.pubmedtypeObservational Study
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.26215
dc.rights.accessRightsopen access
dc.subjectTB
dc.subjectAcute bronchiolitis
dc.subjectBiomarkers
dc.subjectInfections: pneumonia
dc.subjectMyocardial strain
dc.subjectNatriuretic peptides
dc.subjectPulmonary hypertension
dc.subjectUrinary NT-proBNP
dc.subjectViral
dc.subject.decsBiomarcadores
dc.subject.decsBronquiolitis
dc.subject.decsFragmentos de péptidos
dc.subject.decsLactante
dc.subject.decsProyectos piloto
dc.subject.decsPéptido natriurético encefálico
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshBiomarkers
dc.subject.meshBronchiolitis
dc.subject.meshNatriuretic peptide, brain
dc.subject.meshPeptide fragments
dc.subject.meshPilot projects
dc.titleCorrelation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study.
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number58
dspace.entity.typePublication

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