Publication: A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition.
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Identifiers
Date
2022-10-10
Authors
Gallego, Ivan
Ramos-Soriano, Javier
Mendez-Ardoy, Alejandro
Cabrera-Gonzalez, Justo
Lostale-Seijo, Irene
Illescas, Beatriz M
Reina, Jose J
Martin, Nazario
Montenegro, Javier
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Abstract
Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis-adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis-adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E-selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.
Description
MeSH Terms
Biocompatible Materials
E-Selectin
Fullerenes
Ligands
Peptides
E-Selectin
Fullerenes
Ligands
Peptides
DeCS Terms
Híbridos péptido‑fullereno
Multivalencia
E‑Selectina
Fullerenos
Reconocimiento molecular
Andamiajes nanocarbono
Multivalencia
E‑Selectina
Fullerenos
Reconocimiento molecular
Andamiajes nanocarbono
CIE Terms
Keywords
Fullerenes, Glycomimetic, Lectin, Multivalency, Peptides, Centro Andaluz de Nanomedicina y Biotecnología, BIONAND
Citation
Gallego I, Ramos-Soriano J, Méndez-Ardoy A, Cabrera-González J, Lostalé-Seijo I, Illescas BM, et al. A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202210043.