Publication:
A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition.

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Date

2022-10-10

Authors

Gallego, Ivan
Ramos-Soriano, Javier
Mendez-Ardoy, Alejandro
Cabrera-Gonzalez, Justo
Lostale-Seijo, Irene
Illescas, Beatriz M
Reina, Jose J
Martin, Nazario
Montenegro, Javier

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Wiley-VCH Verlag GmbH & Co. KGaA
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Abstract

Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis-adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis-adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E-selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.

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MeSH Terms

Biocompatible Materials
E-Selectin
Fullerenes
Ligands
Peptides

DeCS Terms

Híbridos péptido‑fullereno
Multivalencia
E‑Selectina
Fullerenos
Reconocimiento molecular
Andamiajes nanocarbono

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Keywords

Fullerenes, Glycomimetic, Lectin, Multivalency, Peptides, Centro Andaluz de Nanomedicina y Biotecnología, BIONAND

Citation

Gallego I, Ramos-Soriano J, Méndez-Ardoy A, Cabrera-González J, Lostalé-Seijo I, Illescas BM, et al. A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202210043.