RT Journal Article
T1 A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition.
A1 Gallego, Iván
A1 Ramos-Soriano, Javier
A1 Méndez-Ardoy, Alejandro
A1 Cabrera-González, Justo
A1 Lostalé-Seijo, Irene
A1 Illescas, Beatriz M
A1 Reina, Jose J
A1 Martín, Nazario
A1 Montenegro, Javier
K1 Fullerenes
K1 Glycomimetic
K1 Lectin
K1 Multivalency
K1 Peptides
AB Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis-adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis-adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E-selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.
YR 2022
FD 2022-09-06
LK http://hdl.handle.net/10668/20396
UL http://hdl.handle.net/10668/20396
LA en
DS RISalud
RD Apr 5, 2025