Publication: Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations
Identifiers
Date
2007-12
Authors
Ariza, Javier
Bosilkovski, Mile
Cascio, Antonio
Colmenero, Juan D.
Corbel, Michael J.
Falagas, Matthew E.
Memish, Ziad A.
Roushan, Mohammad Reza Hasanjani
Rubinstein, Ethan
Sipsas, Nikolaos V.
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Metrics
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Abstract
Summary Points
Brucellosis remains the commonest anthropozoonosis worldwide, and its treatment remains complex, requiring protracted administration of more than one antibiotic.
In November 2006, a consensus meeting aimed at reaching a common specialist statement on the treatment of brucellosis was held in Ioannina, Greece under the auspices of the International Society of Chemotherapy and the Institute of Continuing Medical Education of Ioannina.
The author panel suggests that the optimal treatment of uncomplicated brucellosis should be based on a six-week regimen of doxycycline combined either with streptomycin for 2–3 weeks, or rifampicin for six weeks. Gentamicin may be considered an acceptable alternative to streptomycin, while all other regimens/combinations should be considered second-line.
The development of a common global therapeutic language for human brucellosis, and future, properly conducted clinical trials would definitely solve controversies regarding the disease.
Description
Policy Forum. Competing interests: ER has received research grants from Daiichi, Bayer, and Theravance and has served as a consultant to Pfizer, Theravance, Bayer, Wyeth, Rosetta, and BiondVax.
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Brucellosis
Medical Subject Headings::Disciplines and Occupations::Social Sciences::Internationality::International Cooperation::Developing Countries
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Tetracyclines::Doxycycline
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy, Combination
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins
Medical Subject Headings::Humanities::Humanities::History::History, Modern 1601-::History, 21st Century
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds with 4 or More Rings::Rifamycins::Rifampin
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Streptomycin
Medical Subject Headings::Information Science::Information Science::Communication::Language::Linguistics::Terminology as Topic
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Trimethoprim::Trimethoprim-Sulfamethoxazole Combination
Medical Subject Headings::Health Care::Population Characteristics::Health::World Health
Medical Subject Headings::Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Brucellosis
Medical Subject Headings::Disciplines and Occupations::Social Sciences::Internationality::International Cooperation::Developing Countries
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Tetracyclines::Doxycycline
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy, Combination
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins
Medical Subject Headings::Humanities::Humanities::History::History, Modern 1601-::History, 21st Century
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds with 4 or More Rings::Rifamycins::Rifampin
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Streptomycin
Medical Subject Headings::Information Science::Information Science::Communication::Language::Linguistics::Terminology as Topic
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Trimethoprim::Trimethoprim-Sulfamethoxazole Combination
Medical Subject Headings::Health Care::Population Characteristics::Health::World Health
Medical Subject Headings::Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization
Medical Subject Headings::Organisms::Eukaryota::Animals
DeCS Terms
CIE Terms
Keywords
Iraqi patients, Cotrimoxazole, Efficacy, Metaanalysis, Animales, Antibacterianos, Investigación Biomédica, Brucelosis, Países en Desarrollo, Doxiciclina, Combinación de Medicamentos, Resistencia a Medicamentos, Quimioterapia, Fluoroquinolonas, Gentamicinas, Adhesión a Directriz, Historia del Siglo XXI, Humanos, Recurrencia, Estreptomicina, Terminología como Asunto, Resultado del Tratamiento, Combinación Trimetoprim-Sulfametoxazol, Salud Mundial, Organización Mundial de la Salud
Citation
Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagas ME, et al. Perspectives for the treatment of brucellosis in the 21st century: The ioannina recommendations. Plos Med. 2007 Dec;4(12):1872-8