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An inhibitory pull-push circuit in frontal cortex.

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dc.contributor.authorGarcia-Junco-Clemente, Pablo
dc.contributor.authorIkrar, Taruna
dc.contributor.authorTring, Elaine
dc.contributor.authorXu, Xiangmin
dc.contributor.authorRingach, Dario L
dc.contributor.authorTrachtenberg, Joshua T
dc.date.accessioned2023-01-25T09:43:06Z
dc.date.available2023-01-25T09:43:06Z
dc.date.issued2017-01-23
dc.description.abstractPush-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.
dc.description.versionSi
dc.identifier.citationGarcia-Junco-Clemente P, Ikrar T, Tring E, Xu X, Ringach DL, Trachtenberg JT. An inhibitory pull-push circuit in frontal cortex. Nat Neurosci. 2017 Mar;20(3):389-392.
dc.identifier.doi10.1038/nn.4483
dc.identifier.essn1546-1726
dc.identifier.pmcPMC5967235
dc.identifier.pmid28114295
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967235/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5967235?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/10797
dc.issue.number3
dc.journal.titleNature neuroscience
dc.journal.titleabbreviationNat Neurosci
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number13
dc.provenanceRealizada la curación de contenido 12/03/2025
dc.publisherNature Publishing Group
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://doi.org/10.1038/nn.4483
dc.rights.accessRightsRestricted Access
dc.subjectNeural circuits
dc.subjectCellular neuroscience
dc.subject.decsCélulas piramidales
dc.subject.decsNivel de alerta
dc.subject.decsCélulas
dc.subject.decsLóbulo frontal
dc.subject.decsNeuronas
dc.subject.decsRetroalimentación
dc.subject.decsInterneuronas
dc.subject.decsPéptido intestinal vasoactivo
dc.subject.meshAnimals
dc.subject.meshArousal
dc.subject.meshChannelrhodopsins
dc.subject.meshFeedback, Physiological
dc.subject.meshFemale
dc.subject.meshFrontal Lobe
dc.subject.meshInterneurons
dc.subject.meshLocomotion
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Transgenic
dc.subject.meshNeural Inhibition
dc.subject.meshPupil
dc.subject.meshPyramidal Cells
dc.subject.meshVasoactive Intestinal Peptide
dc.titleAn inhibitory pull-push circuit in frontal cortex.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number20
dspace.entity.typePublication

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