Publication: An inhibitory pull-push circuit in frontal cortex.
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Identifiers
Date
2017-01-23
Authors
Garcia-Junco-Clemente, Pablo
Ikrar, Taruna
Tring, Elaine
Xu, Xiangmin
Ringach, Dario L
Trachtenberg, Joshua T
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
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Abstract
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.
Description
MeSH Terms
Animals
Arousal
Channelrhodopsins
Feedback, Physiological
Female
Frontal Lobe
Interneurons
Locomotion
Male
Mice
Mice, Transgenic
Neural Inhibition
Pupil
Pyramidal Cells
Vasoactive Intestinal Peptide
Arousal
Channelrhodopsins
Feedback, Physiological
Female
Frontal Lobe
Interneurons
Locomotion
Male
Mice
Mice, Transgenic
Neural Inhibition
Pupil
Pyramidal Cells
Vasoactive Intestinal Peptide
DeCS Terms
Células piramidales
Nivel de alerta
Células
Lóbulo frontal
Neuronas
Retroalimentación
Interneuronas
Péptido intestinal vasoactivo
Nivel de alerta
Células
Lóbulo frontal
Neuronas
Retroalimentación
Interneuronas
Péptido intestinal vasoactivo
CIE Terms
Keywords
Neural circuits, Cellular neuroscience
Citation
Garcia-Junco-Clemente P, Ikrar T, Tring E, Xu X, Ringach DL, Trachtenberg JT. An inhibitory pull-push circuit in frontal cortex. Nat Neurosci. 2017 Mar;20(3):389-392.