Publication: Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir.
Loading...
Identifiers
Date
2022-03-25
Authors
Moreno, Santiago
Alcázar, Bernardino
Dueñas, Carlos
González Del Castillo, Juan
Olalla, Julián
Antela, Antonio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of antiviral agents in general and remdesivir in COVID-19 patients. This review evaluated a battery of antiviral compounds and their effectiveness in the treatment of COVID-19 since the beginning of the pandemic. Remdesivir is the only antiviral approved by the EMA and FDA for the treatment of SARS-CoV-2 infection. This work extensively reviews remdesivir data generated from clinical trials and observational studies, paying attention to the most recent data, and focusing on outcomes to give readers a more comprehensive understanding of the results. This review also discusses the recommendations issued by official bodies during the pandemic in the light of the current knowledge. The use of remdesivir in the treatment of SARS-CoV-2 infection is justified because a virus is the causative agent that triggers the inflammatory responses and its consequences. More trials are needed to improve the management of this disease.
Description
MeSH Terms
Adenosine Monophosphate
Alanine
Antiviral Agents
Humans
SARS-CoV-2
Virus Replication
COVID-19 Drug Treatment
Alanine
Antiviral Agents
Humans
SARS-CoV-2
Virus Replication
COVID-19 Drug Treatment
DeCS Terms
CIE Terms
Keywords
COVID-19, anti-viral therapy, recommendations, viral RNA polymerases