RT Journal Article
T1 Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir.
A1 Moreno, Santiago
A1 Alcázar, Bernardino
A1 Dueñas, Carlos
A1 González Del Castillo, Juan
A1 Olalla, Julián
A1 Antela, Antonio
K1 COVID-19
K1 anti-viral therapy
K1 recommendations
K1 viral RNA polymerases
AB The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of antiviral agents in general and remdesivir in COVID-19 patients. This review evaluated a battery of antiviral compounds and their effectiveness in the treatment of COVID-19 since the beginning of the pandemic. Remdesivir is the only antiviral approved by the EMA and FDA for the treatment of SARS-CoV-2 infection. This work extensively reviews remdesivir data generated from clinical trials and observational studies, paying attention to the most recent data, and focusing on outcomes to give readers a more comprehensive understanding of the results. This review also discusses the recommendations issued by official bodies during the pandemic in the light of the current knowledge. The use of remdesivir in the treatment of SARS-CoV-2 infection is justified because a virus is the causative agent that triggers the inflammatory responses and its consequences. More trials are needed to improve the management of this disease.
YR 2022
FD 2022-03-25
LK http://hdl.handle.net/10668/20459
UL http://hdl.handle.net/10668/20459
LA en
DS RISalud
RD Apr 17, 2025