Publication:
Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology.

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Date

2022-07-21

Authors

Moya-García, Aurelio A
González-Jiménez, Andrés
Moreno, Fernando
Stephens, Camilla
Lucena, María Isabel
Ranea, Juan A G

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Abstract

Among adverse drug reactions, drug-induced liver injury presents particular challenges because of its complexity, and the underlying mechanisms are still not completely characterized. Our knowledge of the topic is limited and based on the assumption that a drug acts on one molecular target. We have leveraged drug polypharmacology, i.e., the ability of a drug to bind multiple targets and thus perturb several biological processes, to develop a systems pharmacology platform that integrates all drug-target interactions. Our analysis sheds light on the molecular mechanisms of drugs involved in drug-induced liver injury and provides new hypotheses to study this phenomenon.

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Chemical and Drug Induced Liver Injury
Drug-Related Side Effects and Adverse Reactions
Humans
Network Pharmacology
Polypharmacology

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drug-induced liver injury, polypharmacology, systems pharmacology, toxicology

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