RT Journal Article
T1 Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology.
A1 Moya-García, Aurelio A
A1 González-Jiménez, Andrés
A1 Moreno, Fernando
A1 Stephens, Camilla
A1 Lucena, María Isabel
A1 Ranea, Juan A G
K1 drug-induced liver injury
K1 polypharmacology
K1 systems pharmacology
K1 toxicology
AB Among adverse drug reactions, drug-induced liver injury presents particular challenges because of its complexity, and the underlying mechanisms are still not completely characterized. Our knowledge of the topic is limited and based on the assumption that a drug acts on one molecular target. We have leveraged drug polypharmacology, i.e., the ability of a drug to bind multiple targets and thus perturb several biological processes, to develop a systems pharmacology platform that integrates all drug-target interactions. Our analysis sheds light on the molecular mechanisms of drugs involved in drug-induced liver injury and provides new hypotheses to study this phenomenon.
YR 2022
FD 2022-07-21
LK http://hdl.handle.net/10668/20981
UL http://hdl.handle.net/10668/20981
LA en
DS RISalud
RD Apr 4, 2025