Publication: Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can affect it.
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Identifiers
Date
2019-09-03
Authors
Boto, Luis
Pineda, Manuel
Pineda, Rafael
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Blackwell Publishing
Abstract
Horizontal gene transfer (HGT) is widespread among prokaryotes driving their evolution. In this paper, we review the potential impact in humans of the HGT between prokaryotes living in close association with humans in two scenarios: horizontal transfer in human microbiomes and transfer between microbes living in human managed environments. Although our vision is focused on the possible impact of these transfers in the propagation of antibiotic resistance genes or pathogenicity determinants, we also discuss possible human physiological adaptations via gene transfer between resident and occasional bacteria in the human microbiome.
Description
MeSH Terms
Bacteria
Bacterial proteins
Biodiversity
Gene transfer, horizontal
Genome, bacterial
Humans
Microbiota
Bacterial proteins
Biodiversity
Gene transfer, horizontal
Genome, bacterial
Humans
Microbiota
DeCS Terms
Bacterias
Biodiversidad
Genoma bacteriano
Microbiota
Proteínas bacterianas
Transferencia de gen horizontal
Biodiversidad
Genoma bacteriano
Microbiota
Proteínas bacterianas
Transferencia de gen horizontal
CIE Terms
Keywords
Horizontal gene transfer, Human managed environments, Human microbiome, Nutritional adaptations, Pathogenicity determinants, Resistome, Somatic gene transfer
Citation
Boto L, Pineda M, Pineda R. Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can affect it. FEBS J. 2019 Oct;286(20):3959-3967