RT Journal Article
T1 Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can affect it.
A1 Boto, Luis
A1 Pineda, Manuel
A1 Pineda, Rafael
K1 Horizontal gene transfer
K1 Human managed environments
K1 Human microbiome
K1 Nutritional adaptations
K1 Pathogenicity determinants
K1 Resistome
K1 Somatic gene transfer
AB Horizontal gene transfer (HGT) is widespread among prokaryotes driving their evolution. In this paper, we review the potential impact in humans of the HGT between prokaryotes living in close association with humans in two scenarios: horizontal transfer in human microbiomes and transfer between microbes living in human managed environments. Although our vision is focused on the possible impact of these transfers in the propagation of antibiotic resistance genes or pathogenicity determinants, we also discuss possible human physiological adaptations via gene transfer between resident and occasional bacteria in the human microbiome.
PB Wiley-Blackwell Publishing
YR 2019
FD 2019-09-03
LK http://hdl.handle.net/10668/14482
UL http://hdl.handle.net/10668/14482
LA en
NO Boto L, Pineda M, Pineda R. Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can affect it. FEBS J. 2019 Oct;286(20):3959-3967
NO The authors thank the two anonymous referees fortheir valuable comments. LB is supported by the grantCGL2016-75262-P of Spain DGI. RP is supported bya postdoctoral contract (Submodality 5.2.A) funded bythe Research Plan of the University of Cordoba. Fig-ure in the graphical abstract is a modified image fromthe Gerd Altmann in Pixabay
DS RISalud
RD Apr 8, 2025