Publication:
Aging-associated oxidized albumin promotes cellular senescence and endothelial damage.

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Date

2016-02-29

Authors

Luna, Carlos
Alique, Matilde
Navalmoral, Estefania
Noci, Maria-Victoria
Bohorquez-Magro, Lourdes
Carracedo, Julia
Ramirez, Rafael

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Dove Medical Press
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Abstract

Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.

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MeSH Terms

Adult
Advanced oxidation protein products
Aged
Aged, 80 and over
Aging
Apoptosis
Biomarkers
Case-control studies
Cells, cultured
Cellular senescence
Endothelial cells
Female
Humans
Male
Oxidation-reduction
Oxidative stress
Risk factors
Serum albumin

DeCS Terms

Albúmina sérica
Biomarcadores
Células cultivadas
Células endoteliales
Estrés oxidativo
Factores de riesgo
Oxidación-reducción
Senescencia celular

CIE Terms

Keywords

Elderly, Microparticles, Oxidative stress, Vascular damage

Citation

Luna C, Alique M, Navalmoral E, Noci MV, Bohorquez-Magro L, Carracedo J, et al. Aging-associated oxidized albumin promotes cellular senescence and endothelial damage. Clin Interv Aging. 2016 Feb 29;11:225-36