RT Journal Article
T1 Aging-associated oxidized albumin promotes cellular senescence and endothelial damage.
A1 Luna, Carlos
A1 Alique, Matilde
A1 Navalmoral, Estefania
A1 Noci, Maria-Victoria
A1 Bohorquez-Magro, Lourdes
A1 Carracedo, Julia
A1 Ramirez, Rafael
K1 Elderly
K1 Microparticles
K1 Oxidative stress
K1 Vascular damage
AB Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.
PB Dove Medical Press
YR 2016
FD 2016-02-29
LK http://hdl.handle.net/10668/9969
UL http://hdl.handle.net/10668/9969
LA en
NO Luna C, Alique M, Navalmoral E, Noci MV, Bohorquez-Magro L, Carracedo J, et al. Aging-associated oxidized albumin promotes cellular senescence and endothelial damage. Clin Interv Aging. 2016 Feb 29;11:225-36
NO We are grateful to María José Jimenez and Rosa Moyano for technical assistance. We also thank Miss Annie Bailey for English and scientific revisions of the manuscript. This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)Fondos Feder European Grants (PI11/01536, PI12/01489, PI014/0041 and PI14/00806); Red de Investigación Renal (REDinREN; RD12/0021/002); Comunidad de Madrid (Fibroteam; S2010/BMD-2321); Junta de Andalucía Grants JA0797-2010, P010-CTS-6337, P11-CTS-7352.
DS RISalud
RD Apr 15, 2025