Publication:
Classification Accuracy of Hepatitis C Virus Infection Outcome: Data Mining Approach.

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Date

2020-12-17

Authors

Frias, Mario
Moyano, Jose M
Rivero-Juarez, Antonio
Luna, Jose M
Camacho, Angela
Fardoun, Habib M
Machuca, Isabel
Al-Twijri, Mohamed
Rivero, Antonio
Ventura, Sebastian

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JMIR Publications
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Abstract

The dataset from genes used to predict hepatitis C virus outcome was evaluated in a previous study using a conventional statistical methodology. The aim of this study was to reanalyze this same dataset using the data mining approach in order to find models that improve the classification accuracy of the genes studied. We built predictive models using different subsets of factors, selected according to their importance in predicting patient classification. We then evaluated each independent model and also a combination of them, leading to a better predictive model. Our data mining approach identified genetic patterns that escaped detection using conventional statistics. More specifically, the partial decision trees and ensemble models increased the classification accuracy of hepatitis C virus outcome compared with conventional methods. Data mining can be used more extensively in biomedicine, facilitating knowledge building and management of human diseases.

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MeSH Terms

Algorithms
Data mining
Hepacivirus
Humans

DeCS Terms

Algoritmos
Hepacivirus
Humanos
Minería de datos

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Keywords

HIV/HCV, PART, Classification accuracy, Data mining, Ensemble

Citation

Frias M, Moyano JM, Rivero-Juarez A, Luna JM, Camacho Á, Fardoun HM, et al. Classification Accuracy of Hepatitis C Virus Infection Outcome: Data Mining Approach. J Med Internet Res. 2021 Feb 24;23(2):e18766