Editorial: Systems Biology Approach to the Immunology of Asthma and Allergy.

Abstract

Theprevalence of allergic diseases as well as their severity have risen progressively during the last decades, affecting a considerable percentage of the population worldwide. Asthma and allergies as a whole are heterogeneous and show acomplexpatternof disease endotypes, a complicated balance between immune tolerance and allergic sensitization, and a progression of allergic diseases. The application of highthroughput technologies enables the profiling of genomes, epigenomes, transcriptomes, microbiomes and metabolomestogainabetter understandingoftheimmunemechanismsunderlyingasthmaandallergies. The use of systems biology aims at combining and connecting the information on the different molecular components on the cell, tissue, or organ level to discover the properties of the full system. A system’s level understanding of the complex allergic diseases will then assist in implementing personalized medicine strategies for the treatment of allergic and asthmatic patients.