Publication:
The spatial pattern of human exposure to Crimean-Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions.

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Date

2022-02-16

Authors

Frias, Mario
Cuadrado-Matias, Raul
Del Castillo Jarilla-Fernandez, Maria
Lopez-Lopez, Pedro
Casades-Marti, Laia
Madrigal, Elena
Rivero, Antonio
Rivero-Juarez, Antonio
Ruiz-Fons, Francisco

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Wiley
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Abstract

The objective of this study was to evaluate the spatial risk of exposure to Crimean-Congo haemorrhagic fever virus (CCHFV) infection of healthy blood donors in an enzootic region with a predicted risk gradient based on a virus-animal interaction risk model. We designed a cross-sectional study to test if the exposure pattern of the human population to CCHFV spatially matches the predicted risk. We randomly selected 1384 donors from different risk gradients and analyzed their sera searching for CCHFV antibodies. None of the selected blood donors showed exposure to CCHFV. This study shows that exposure risk spatial patterns, as predicted from animal-tick-virus models, does not necessarily match the pattern of human-infected tick interactions leading to CCHFV infection and CCHF cases, at least in a region of predicted moderate infection risk. The findings suggest that future studies should bear the potential drivers of tick-human encounter rates into account to more accurately predict risks.

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MeSH Terms

Animals
Cross-sectional studies
Deer
Hemorrhagic fever virus, crimean-congo
Hemorrhagic fever, crimean
Humans
Ticks

DeCS Terms

Ciervos
Estudios transversales
Fiebre hemorrágica de crimea
Garrapatas
Virus de la fiebre hemorrágica de crimea-congo

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Keywords

CCHFV, Blood donors, Enzootic area, Risk gradients, Serosurvey

Citation

Frías M, Cuadrado-Matías R, Del Castillo Jarilla-Fernández M, López-López P, Casades-Martí L, Madrigal E, et al. The spatial pattern of human exposure to Crimean-Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions. Transbound Emerg Dis. 2022 Sep;69(5):e3208-e3214