RT Journal Article
T1 The spatial pattern of human exposure to Crimean-Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions.
A1 Frias, Mario
A1 Cuadrado-Matias, Raul
A1 Del Castillo Jarilla-Fernandez, Maria
A1 Lopez-Lopez, Pedro
A1 Casades-Marti, Laia
A1 Madrigal, Elena
A1 Rivero, Antonio
A1 Rivero-Juarez, Antonio
A1 Ruiz-Fons, Francisco
K1 CCHFV
K1 Blood donors
K1 Enzootic area
K1 Risk gradients
K1 Serosurvey
AB The objective of this study was to evaluate the spatial risk of exposure to Crimean-Congo haemorrhagic fever virus (CCHFV) infection of healthy blood donors in an enzootic region with a predicted risk gradient based on a virus-animal interaction risk model. We designed a cross-sectional study to test if the exposure pattern of the human population to CCHFV spatially matches the predicted risk. We randomly selected 1384 donors from different risk gradients and analyzed their sera searching for CCHFV antibodies. None of the selected blood donors showed exposure to CCHFV. This study shows that exposure risk spatial patterns, as predicted from animal-tick-virus models, does not necessarily match the pattern of human-infected tick interactions leading to CCHFV infection and CCHF cases, at least in a region of predicted moderate infection risk. The findings suggest that future studies should bear the potential drivers of tick-human encounter rates into account to more accurately predict risks.
PB Wiley
YR 2022
FD 2022-02-16
LK http://hdl.handle.net/10668/20021
UL http://hdl.handle.net/10668/20021
LA en
NO Frías M, Cuadrado-Matías R, Del Castillo Jarilla-Fernández M, López-López P, Casades-Martí L, Madrigal E, et al. The spatial pattern of human exposure to Crimean-Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions. Transbound Emerg Dis. 2022 Sep;69(5):e3208-e3214
NO This study was supported by Spanish Ministry for the Science and Innovation, MCI (projects GCL2017-89866-R) and Regional Government of Castilla-La Mancha and the European Social Fund (ESF) (SBPLY/19/180501/000321). RC-M and LC-M acknowledge funding by MCI, ESF and the University of Castilla-La Mancha through contracts PRE2018-083801 and PEJ2018-003155-A, respectively. AR-J and MF are recipients of postdoctoral perfection grants by the SpanishMinistry of Science and Innovation (CP18/00111 and CD18/00091, respectively).
DS RISalud
RD Apr 9, 2025