Publication: Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions
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Identifiers
Date
2017-05-04
Authors
Eduarda de Lima, Maria
Colpo, Ana C.
Maya-Lopez, Marisol
Rosa, Hemerson
Tunez, Isaac
Galvan-Arzate, Sonia
Santamaria, Abel
Folmer, Vanderlei
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier science bv
Abstract
Yerba mate extracts are naturally enriched with several antioxidant compounds. Therefore, this natural product constitutes a fertile field of research directed to test its antioxidant and therapeutic properties in the Central Nervous System. We tested the ability of yerba mate to prevent the chemically-induced reactive oxygen species (ROS) formation, lipid peroxidation, glutathione balance (GSH:GSSG) disruption and mitochondrial dysfunction in vitro in rat brain synaptosomal/mitochondrial fractions, and compared these effects with those of its most abundant compound chlorogenic acid (CGA). Yerba mate prevented glutathione depletion and mitochondrial dysfunction, and these effects were correlated with its ability to prevent ROS formation. CGA prevented oxidative damage and mitochondrial dysfunction, but its effects were less intense than those of the extract. Our results suggest that the protective properties exhibited by yerba mate cannot be merely attributable to its main component CGA.
Description
MeSH Terms
Phenolic-compounds
Mitochondrial dysfunction
Antioxidant activity
Quinolinic acid
Stress
Synaptosomes
Impairment
Proteins
Mitochondrial dysfunction
Antioxidant activity
Quinolinic acid
Stress
Synaptosomes
Impairment
Proteins
DeCS Terms
Antioxidantes
Enfermedades mitocondriales
Proteínas
Sinaptosomas
Ácido quinolínico
Enfermedades mitocondriales
Proteínas
Sinaptosomas
Ácido quinolínico
CIE Terms
Keywords
Antioxidant defense, Rat brain, Mitochondrial dysfunction, Neuroprotection, Yerba mate extract, Chlorogenic acid
Citation
De Lima ME, Colpo AC, Maya-López M, Rosa H, Túnez I, Galván-Arzate S, et al. Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions. Journal Of Functional Foods [Internet]. 1 de julio de 2017;34:447-52