RT Journal Article
T1 Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions
A1 Eduarda de Lima, Maria
A1 Colpo, Ana C.
A1 Maya-Lopez, Marisol
A1 Rosa, Hemerson
A1 Tunez, Isaac
A1 Galvan-Arzate, Sonia
A1 Santamaria, Abel
A1 Folmer, Vanderlei
K1 Antioxidant defense
K1 Rat brain
K1 Mitochondrial dysfunction
K1 Neuroprotection
K1 Yerba mate extract
K1 Chlorogenic acid
AB Yerba mate extracts are naturally enriched with several antioxidant compounds. Therefore, this natural product constitutes a fertile field of research directed to test its antioxidant and therapeutic properties in the Central Nervous System. We tested the ability of yerba mate to prevent the chemically-induced reactive oxygen species (ROS) formation, lipid peroxidation, glutathione balance (GSH:GSSG) disruption and mitochondrial dysfunction in vitro in rat brain synaptosomal/mitochondrial fractions, and compared these effects with those of its most abundant compound chlorogenic acid (CGA). Yerba mate prevented glutathione depletion and mitochondrial dysfunction, and these effects were correlated with its ability to prevent ROS formation. CGA prevented oxidative damage and mitochondrial dysfunction, but its effects were less intense than those of the extract. Our results suggest that the protective properties exhibited by yerba mate cannot be merely attributable to its main component CGA. 
PB Elsevier science bv
SN 1756-4646
YR 2017
FD 2017-05-04
LK http://hdl.handle.net/10668/18816
UL http://hdl.handle.net/10668/18816
LA en
NO De Lima ME, Colpo AC, Maya-López M, Rosa H, Túnez I, Galván-Arzate S, et al. Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions. Journal Of Functional Foods [Internet]. 1 de julio de 2017;34:447-52
NO This work was supported by CONACyT (Mexico) Grant 205648 (A.S.) and CAPES (Brazil) Grants (99999.006894/2015-01 for M.E. L. and  99999.006340/2015-06 for A.C.C.).
DS RISalud
RD Apr 6, 2025