Publication: Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury.
dc.contributor.author | Ortega-Alonso, Aida | |
dc.contributor.author | Stephens, Camilla | |
dc.contributor.author | Lucena, M Isabel | |
dc.contributor.author | Andrade, Raúl J | |
dc.contributor.authoraffiliation | [Ortega-Alonso, Aida] Univ Malaga, Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad | |
dc.contributor.authoraffiliation | [Ortega-Alonso, Aida] Univ Malaga, Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Enfermedades Digest & Farmacol C, E-29071 Malaga, Spain | |
dc.contributor.authoraffiliation | [Stephens, Camilla] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain | |
dc.contributor.authoraffiliation | [Isabel Lucena, M.] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain | |
dc.contributor.authoraffiliation | [Andrade, Raul J.] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain | |
dc.contributor.funder | Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional—FEDER | |
dc.contributor.funder | Agencia Española del Medicamento | |
dc.date.accessioned | 2023-01-25T08:32:36Z | |
dc.date.available | 2023-01-25T08:32:36Z | |
dc.date.issued | 2016-05-12 | |
dc.description.abstract | Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and dietary supplements) presents with a range of both phenotypes and severity, from acute hepatitis indistinguishable of viral hepatitis to autoimmune syndromes, steatosis or rare chronic vascular syndromes, and from asymptomatic liver test abnormalities to acute liver failure. DILI pathogenesis is complex, depending on the interaction of drug physicochemical properties and host factors. The awareness of risk factors for DILI is arising from the analysis of large databases of DILI cases included in Registries and Consortia networks around the world. These networks are also enabling in-depth phenotyping with the identification of predictors for severe outcome, including acute liver failure and mortality/liver transplantation. Genome wide association studies taking advantage of these large cohorts have identified several alleles from the major histocompatibility complex system indicating a fundamental role of the adaptive immune system in DILI pathogenesis. Correct case definition and characterization is crucial for appropriate phenotyping, which in turn will strengthen sample collection for genotypic and future biomarkers studies. | |
dc.description.sponsorship | The present study has been supported by grants of the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional—FEDER (contract numbers: PI12/00378, SAS-PI-0239/2012, AC-0073-2013) and by the Agencia Española del Medicamento. CIBERehd is funded by Instituto de Salud Carlos III. | |
dc.description.version | Si | |
dc.identifier.citation | Ortega-Alonso A, Stephens C, Lucena MI, Andrade RJ. Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury. Int J Mol Sci. 2016 May 12;17(5):714. | |
dc.identifier.doi | 10.3390/ijms17050714 | |
dc.identifier.essn | 1422-0067 | |
dc.identifier.pmc | PMC4881536 | |
dc.identifier.pmid | 27187363 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881536/pdf | |
dc.identifier.unpaywallURL | https://www.mdpi.com/1422-0067/17/5/714/pdf?version=1463051975 | |
dc.identifier.uri | http://hdl.handle.net/10668/10092 | |
dc.issue.number | 5 | |
dc.journal.title | International journal of molecular sciences | |
dc.journal.titleabbreviation | Int J Mol Sci | |
dc.language.iso | en | |
dc.organization | IBIMA | |
dc.page.number | 22 | |
dc.provenance | Realizada la curación de contenido 26/08/2025. | |
dc.publisher | MDPI AG | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Review | |
dc.relation.projectID | PI12/00378 | |
dc.relation.projectID | SAS-PI-0239/2012 | |
dc.relation.projectID | AC-0073-2013 | |
dc.relation.publisherversion | https://www.mdpi.com/resolver?pii=ijms17050714 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | DILI | |
dc.subject | drug-induced liver injury | |
dc.subject | risk factors | |
dc.subject.decs | Concienciación | |
dc.subject.decs | Hepatitis | |
dc.subject.decs | Sistema inmunológico | |
dc.subject.decs | Hígado | |
dc.subject.decs | Biomarcadores | |
dc.subject.decs | Fallo hepático agudo | |
dc.subject.decs | Trasplante de hígado | |
dc.subject.decs | Suplementos dietéticos | |
dc.subject.mesh | Chemical and Drug Induced Liver Injury | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.title | Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury. | |
dc.type | review | |
dc.type.hasVersion | VoR | |
dc.volume.number | 17 | |
dspace.entity.type | Publication |
Files
Original bundle
1 - 1 of 1