Publication:
Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury.

dc.contributor.authorOrtega-Alonso, Aida
dc.contributor.authorStephens, Camilla
dc.contributor.authorLucena, M Isabel
dc.contributor.authorAndrade, Raúl J
dc.contributor.authoraffiliation[Ortega-Alonso, Aida] Univ Malaga, Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad
dc.contributor.authoraffiliation[Ortega-Alonso, Aida] Univ Malaga, Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Enfermedades Digest & Farmacol C, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Stephens, Camilla] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
dc.contributor.authoraffiliation[Isabel Lucena, M.] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
dc.contributor.authoraffiliation[Andrade, Raul J.] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
dc.contributor.funderInstituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional—FEDER
dc.contributor.funderAgencia Española del Medicamento
dc.date.accessioned2023-01-25T08:32:36Z
dc.date.available2023-01-25T08:32:36Z
dc.date.issued2016-05-12
dc.description.abstractIdiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and dietary supplements) presents with a range of both phenotypes and severity, from acute hepatitis indistinguishable of viral hepatitis to autoimmune syndromes, steatosis or rare chronic vascular syndromes, and from asymptomatic liver test abnormalities to acute liver failure. DILI pathogenesis is complex, depending on the interaction of drug physicochemical properties and host factors. The awareness of risk factors for DILI is arising from the analysis of large databases of DILI cases included in Registries and Consortia networks around the world. These networks are also enabling in-depth phenotyping with the identification of predictors for severe outcome, including acute liver failure and mortality/liver transplantation. Genome wide association studies taking advantage of these large cohorts have identified several alleles from the major histocompatibility complex system indicating a fundamental role of the adaptive immune system in DILI pathogenesis. Correct case definition and characterization is crucial for appropriate phenotyping, which in turn will strengthen sample collection for genotypic and future biomarkers studies.
dc.description.sponsorshipThe present study has been supported by grants of the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional—FEDER (contract numbers: PI12/00378, SAS-PI-0239/2012, AC-0073-2013) and by the Agencia Española del Medicamento. CIBERehd is funded by Instituto de Salud Carlos III.
dc.description.versionSi
dc.identifier.citationOrtega-Alonso A, Stephens C, Lucena MI, Andrade RJ. Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury. Int J Mol Sci. 2016 May 12;17(5):714.
dc.identifier.doi10.3390/ijms17050714
dc.identifier.essn1422-0067
dc.identifier.pmcPMC4881536
dc.identifier.pmid27187363
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881536/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/17/5/714/pdf?version=1463051975
dc.identifier.urihttp://hdl.handle.net/10668/10092
dc.issue.number5
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationIBIMA
dc.page.number22
dc.provenanceRealizada la curación de contenido 26/08/2025.
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.projectIDPI12/00378
dc.relation.projectIDSAS-PI-0239/2012
dc.relation.projectIDAC-0073-2013
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=ijms17050714
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDILI
dc.subjectdrug-induced liver injury
dc.subjectrisk factors
dc.subject.decsConcienciación
dc.subject.decsHepatitis
dc.subject.decsSistema inmunológico
dc.subject.decsHígado
dc.subject.decsBiomarcadores
dc.subject.decsFallo hepático agudo
dc.subject.decsTrasplante de hígado
dc.subject.decsSuplementos dietéticos
dc.subject.meshChemical and Drug Induced Liver Injury
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.titleCase Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury.
dc.typereview
dc.type.hasVersionVoR
dc.volume.number17
dspace.entity.typePublication

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