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Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).

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2019

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Fernández Rodríguez, Conrado M
Aller, Rocío
Gutiérrez García, María Luisa
Ampuero, Javier
Gómez-Camarero, Judith
Martín-Mateos, Rosa M ª
Burgos-Santamaría, Diego
Rosales, José Miguel
Aspichueta, Patricia
Buque, Xabier

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Abstract

recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, diabetes mellitus, arterial hypertension, and renal and cardiac disease. Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis. six hundred and thirty-four patients from the nation-wide HEPAMET registry with biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuricemia is related with advanced liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Patients were divided into three groups according to the tertile levels of serum uric acid and gender. the cohort was composed of 50% females, with a mean age of 49 years (range 19-80). Patients in the top third of serum uric acid levels were older (p = 0.017); they had a higher body mass index (p higher levels of serum uric acid were independently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Serum uric acid levels warrants further evaluation as a component of the current non-invasive NAFLD scores of histopathological damage.

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Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Biomarkers
Body Mass Index
Cholesterol
Cholesterol, HDL
Creatinine
Fatty Liver
Female
Humans
Hyperuricemia
Liver
Liver Cirrhosis
Logistic Models
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Registries
Retrospective Studies
Sex Factors
Triglycerides
Uric Acid
Young Adult

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