RT Journal Article
T1 Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).
A1 Fernández Rodríguez, Conrado M
A1 Aller, Rocío
A1 Gutiérrez García, María Luisa
A1 Ampuero, Javier
A1 Gómez-Camarero, Judith
A1 Martín-Mateos, Rosa M ª
A1 Burgos-Santamaría, Diego
A1 Rosales, José Miguel
A1 Aspichueta, Patricia
A1 Buque, Xabier
A1 Latorre, Mercedes
A1 Andrade, Raúl J
A1 Hernández-Guerra, Manuel
A1 Romero-Gómez, Manuel
AB recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, diabetes mellitus, arterial hypertension, and renal and cardiac disease. Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis. six hundred and thirty-four patients from the nation-wide HEPAMET registry with biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuricemia is related with advanced liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Patients were divided into three groups according to the tertile levels of serum uric acid and gender. the cohort was composed of 50% females, with a mean age of 49 years (range 19-80). Patients in the top third of serum uric acid levels were older (p = 0.017); they had a higher body mass index (p  higher levels of serum uric acid were independently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Serum uric acid levels warrants further evaluation as a component of the current non-invasive NAFLD scores of histopathological damage.
SN 1130-0108
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13631
UL http://hdl.handle.net/10668/13631
LA en
DS RISalud
RD Apr 5, 2025