Publication: Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia.
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Identifiers
Date
2020-10-21
Authors
de Melo, Gessika Araujo
de Oliveira, Eliane Araujo
Dos Santos Andrade, Suellen Mary Marinho
Fernandez-Calvo, Bernardino
Torro, Nelson
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Transcranial Direct Current Stimulation (tDCS) has been used as an alternative treatment for pain reduction in fibromyalgia. In this study, in addition to behavioral measures, we analyzed oscillations in alpha 2 frequency band in the frontal, occipital, and parietal regions, in response to the application of two neuromodulation protocols in fibromyalgia. The study was a randomized, double-blind, placebo-controlled clinical trial with 31 women diagnosed with fibromyalgia. The participants were allocated to three groups with the anodic stimulation applied on the left motor cortex: Group 1, for five consecutive days; Group 2, for 10 consecutive days; and Group 3, sham stimulation for five consecutive days. Statistical analysis showed a reduction in pain intensity after treatment for groups in general [F (1.28) = 8.02; p = 0.008; η2 = 0.223], in addition to a reduction in alpha 2 in the frontal (p = 0.039; d = 0.384) and parietal (p = 0.021; d = 0.520) regions after the treatment on five consecutive days. We conclude that neuromodulation protocols produced similar effects on pain reduction, but differed with respect to the changes in the alpha 2 frequency band in the frontal and parietal regions.
Description
MeSH Terms
Adult
Deep brain stimulation
Double-blind method
Electric stimulation
Electric stimulation therapy
Electroencephalography
Electrophysiology
Female
Fibromyalgia
Humans
Middle aged
Neurosciences
Pain
Pain management
Deep brain stimulation
Double-blind method
Electric stimulation
Electric stimulation therapy
Electroencephalography
Electrophysiology
Female
Fibromyalgia
Humans
Middle aged
Neurosciences
Pain
Pain management
DeCS Terms
Electroencefalografía
Electrofisiología
Estimulación eléctrica
Estimulación encefálica profunda
Fibromialgia
Manejo del dolor
Electrofisiología
Estimulación eléctrica
Estimulación encefálica profunda
Fibromialgia
Manejo del dolor
CIE Terms
Keywords
Citation
de Melo GA, de Oliveira EA, Dos Santos Andrade SMM, Fernández-Calvo B, Torro N. Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia. Sci Rep. 2020 Nov 3;10(1):18955