RT Journal Article T1 Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia. A1 de Melo, Gessika Araujo A1 de Oliveira, Eliane Araujo A1 Dos Santos Andrade, Suellen Mary Marinho A1 Fernandez-Calvo, Bernardino A1 Torro, Nelson AB Transcranial Direct Current Stimulation (tDCS) has been used as an alternative treatment for pain reduction in fibromyalgia. In this study, in addition to behavioral measures, we analyzed oscillations in alpha 2 frequency band in the frontal, occipital, and parietal regions, in response to the application of two neuromodulation protocols in fibromyalgia. The study was a randomized, double-blind, placebo-controlled clinical trial with 31 women diagnosed with fibromyalgia. The participants were allocated to three groups with the anodic stimulation applied on the left motor cortex: Group 1, for five consecutive days; Group 2, for 10 consecutive days; and Group 3, sham stimulation for five consecutive days. Statistical analysis showed a reduction in pain intensity after treatment for groups in general [F (1.28) = 8.02; p = 0.008; η2 = 0.223], in addition to a reduction in alpha 2 in the frontal (p = 0.039; d = 0.384) and parietal (p = 0.021; d = 0.520) regions after the treatment on five consecutive days. We conclude that neuromodulation protocols produced similar effects on pain reduction, but differed with respect to the changes in the alpha 2 frequency band in the frontal and parietal regions. PB Nature Publishing Group YR 2020 FD 2020-10-21 LK http://hdl.handle.net/10668/16539 UL http://hdl.handle.net/10668/16539 LA en NO de Melo GA, de Oliveira EA, Dos Santos Andrade SMM, Fernández-Calvo B, Torro N. Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia. Sci Rep. 2020 Nov 3;10(1):18955 NO Tis work was supported in part by funding from the Brazilian National Council for Scientifc and Technological Development – CNPQ (nº 307366/2017-0, nº 311910/2017-3), Beatriz Galindo Programme of General Secretariat of Universities at the Ministry of Science, Innovation, and Universities (BGP18/00077) to BF-C; and Grant 008/2019, Paraíba State Research Foundation (FAPESQ). DS RISalud RD Apr 10, 2025