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Dual Therapy With Darunavir and Ritonavir Plus Lamivudine vs Triple Therapy With Darunavir and Ritonavir Plus Tenofovir Disoproxil Fumarate and Emtricitabine or Abacavir and Lamivudine for Maintenance of Human Immunodeficiency Virus Type 1 Viral Suppression: Randomized, Open-Label, Noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial

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dc.contributor.authorPulido, Federico
dc.contributor.authorRibera, Esteban
dc.contributor.authorLagarde, Maria
dc.contributor.authorPerez-Valero, Ignacio
dc.contributor.authorPalacios, Rosario
dc.contributor.authorIribarren, Jose A.
dc.contributor.authorPayeras, Antoni
dc.contributor.authorDomingo, Pere
dc.contributor.authorSanz, Jose
dc.contributor.authorCervero, Miguel
dc.contributor.authorCurran, Adrian
dc.contributor.authorRodriguez-Gomez, Francisco J.
dc.contributor.authorTellez, Maria J.
dc.contributor.authorRyan, Pablo
dc.contributor.authorBarrufet, Pilar
dc.contributor.authorKnobel, Hernando
dc.contributor.authorRivero, Antonio
dc.contributor.authorAlejos, Belen
dc.contributor.authorYllescas, Maria
dc.contributor.authorArribas, Jose R.
dc.contributor.authorDUAL-GESIDA-8014-RIS-EST45 Study G
dc.contributor.authoraffiliation[Pulido, Federico] UCM, Imas12, Hosp Univ Doce Octubre, Madrid, Spain
dc.contributor.authoraffiliation[Lagarde, Maria] UCM, Imas12, Hosp Univ Doce Octubre, Madrid, Spain
dc.contributor.authoraffiliation[Ribera, Esteban] Hosp Univ Vall dHebron, Barcelona, Spain
dc.contributor.authoraffiliation[Curran, Adrian] Hosp Univ Vall dHebron, Barcelona, Spain
dc.contributor.authoraffiliation[Perez-Valero, Ignacio] Hosp La Paz, IdiPAZ, Madrid, Spain
dc.contributor.authoraffiliation[Arribas, Jose R.] Hosp La Paz, IdiPAZ, Madrid, Spain
dc.contributor.authoraffiliation[Palacios, Rosario] Hosp Clin Univ Virgen de la Victoria, IBIMA, Malaga, Spain
dc.contributor.authoraffiliation[Iribarren, Jose A.] Hosp Univ Donostia, Inst Invest BioDonostia, San Sebastian, Spain
dc.contributor.authoraffiliation[Payeras, Antoni] Hosp Son Llatzer, Palma De Mallorca, Spain
dc.contributor.authoraffiliation[Domingo, Pere] Hosp Santa Creu & Sant Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Sanz, Jose] Hosp Principe Asturias, Madrid, Spain
dc.contributor.authoraffiliation[Cervero, Miguel] Hosp Univ Severo Ochoa, Madrid, Spain
dc.contributor.authoraffiliation[Rodriguez-Gomez, Francisco J.] Hosp Infanta Elena, Huelva, Spain
dc.contributor.authoraffiliation[Tellez, Maria J.] Hosp Clin Madrid, Madrid, Spain
dc.contributor.authoraffiliation[Ryan, Pablo] Hosp Univ Infanta Leonor, Madrid, Spain
dc.contributor.authoraffiliation[Barrufet, Pilar] Hosp Mataro, Barcelona, Spain
dc.contributor.authoraffiliation[Knobel, Hernando] Hosp del Mar, Barcelona, Spain
dc.contributor.authoraffiliation[Rivero, Antonio] Hosp Univ Reina Sofia, IMIBIC, Cordoba, Spain
dc.contributor.authoraffiliation[Alejos, Belen] Ctr Nacl Epidemiol, Madrid, Spain
dc.contributor.authoraffiliation[Yllescas, Maria] Fdn SEIMC Gesida, Madrid, Spain
dc.contributor.funderRed Tematica Cooperativa de Investigacion en SIDA
dc.contributor.funderFundacion SEIMC-Gesida
dc.contributor.funderJanssen Pharmaceutical
dc.contributor.funderRed Espanola de Investigacion en Sida (RIS)
dc.date.accessioned2023-02-12T02:21:23Z
dc.date.available2023-02-12T02:21:23Z
dc.date.issued2017-12-15
dc.description.abstractBackground. Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-1) suppression.Methods. This was a multicenter, open-label, noninferiority trial (margin 12%). Patients with HIV-1 RNA
dc.identifier.doi10.1093/cid/cix734
dc.identifier.essn1537-6591
dc.identifier.issn1058-4838
dc.identifier.unpaywallURLhttps://academic.oup.com/cid/article-pdf/65/12/2112/21968140/cix734.pdf
dc.identifier.urihttp://hdl.handle.net/10668/18942
dc.identifier.wosID416494500022
dc.issue.number12
dc.journal.titleClinical infectious diseases
dc.journal.titleabbreviationClin. infect. dis.
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.organizationHospital Infanta Elena
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Virgen de la Victoria
dc.page.number2112-2118
dc.publisherOxford univ press inc
dc.rights.accessRightsopen access
dc.subjectdarunavir/ritonavir
dc.subjectlamivudine
dc.subjectswitch
dc.subjectdual therapy
dc.subjectNon-inferiority trial
dc.subjectReverse-transcriptase inhibitor
dc.subjectVirologically stable patients
dc.subjectBoosted protease inhibitor
dc.subjectAntiretroviral therapy
dc.subjectCoformulated elvitegravir
dc.subject2 nucleos(t)ides
dc.subjectPhase 3b
dc.subjectSimplification
dc.subjectHiv
dc.subject.meshAdult
dc.subject.meshAdult
dc.subject.meshAnti-HIV Agents
dc.subject.meshCD4 Lymphocyte Count
dc.subject.meshDarunavir
dc.subject.meshDideoxynucleosides
dc.subject.meshEmtricitabine
dc.subject.meshFemale
dc.subject.meshHIV Infections
dc.subject.meshHIV Protease Inhibitors
dc.subject.meshHIV-1
dc.subject.meshHumans
dc.subject.meshLamivudine
dc.subject.meshMale
dc.subject.meshMedication Therapy Management
dc.subject.meshMiddle Aged
dc.subject.meshRNA, Viral
dc.subject.meshRitonavir
dc.subject.meshTenofovir
dc.subject.meshViral Load
dc.titleDual Therapy With Darunavir and Ritonavir Plus Lamivudine vs Triple Therapy With Darunavir and Ritonavir Plus Tenofovir Disoproxil Fumarate and Emtricitabine or Abacavir and Lamivudine for Maintenance of Human Immunodeficiency Virus Type 1 Viral Suppression: Randomized, Open-Label, Noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number65
dc.wostypeArticle
dspace.entity.typePublication

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SAS - Hospital Universitario Reina Sofía
Instituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)
Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)
SAS - Hospital Infanta Elena
SAS - Hospital Universitario Virgen de la Victoria

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